Operative factors, not hemodynamics, modify hormones in repair of coarctation
| Autor: | Thomas J. Langdon, Richard J. Declusin, Gordon N. Olinger, Lawrence I. Bonchek, Lawrence E. Boerboom, Tie-Zhu Liu |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Hemodynamics Aorta Thoracic Blood Pressure Plasma renin activity Aortic Coarctation Catheterization Renal Circulation Norepinephrine Dogs medicine.artery Renin Medicine Thoracic aorta Animals Aorta Abdominal Aortic Pulse Pressure Cardiac Output Surgical repair Aorta business.industry Anastomosis Surgical Constriction Surgery Pulse pressure Blood pressure business |
| Zdroj: | The Journal of surgical research. 47(2) |
| ISSN: | 0022-4804 |
| Popis: | This study was designed to evaluate separately the influence of restoration of distal pulse pressure and the influence of factors related to operation upon hemodynamic and hormonal alterations accompanying repair of canine aortic coarctation. Eight normal adult dogs underwent a sham operation and served as controls. In 10 dogs the thoracic aorta was transected and reanastomosed. In 10 dogs aortic coarctation was created within 1 week of birth by banding the aorta just proximal to the ductus ligament, thereby fixing lumenal diameter at 1 to 2 mm. Studies were performed in the latter animals 18 months after operation. These dogs were subdivided into two groups: one ( n = 6) underwent surgical repair of the coarctation; in the other ( n = 4), the coarctation was repaired and an occluder was placed on the aorta to maintain distal aortic pulse pressure at its diminished preoperative level. Normal distal pulse pressure was restored in these animals by releasing the occluder 1 week after recovery from the repair of coarctation. Each dog was studied in the conscious state before the definitive procedure and again 24 hr later. Plasma renin activity increased significantly after operation in the sham and in the transection groups. Renin activity and proximal blood pressure were significantly elevated and distal pulse pressure was diminished preoperatively in both the repair and the occluder groups. After their respective definitive procedures, the elevation in renin activity and in proximal pressure persisted in the repair group but decreased in the occluder group. This suggests that continued elevation of renin activity and blood pressure in the early postoperative period following repair of coarctation may be secondary to perioperative rather than hemodynamic factors. |
| Databáze: | OpenAIRE |
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