Chromosomal imbalances and NF2 mutational analysis in a series of 10 spinal nerve sheath myxomas
| Autor: | E. M. Schwering, J. Siebers, Werner Paulus, Christian Hartmann, A. von Deimling, C. H. Rickert |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Histology DNA Mutational Analysis Biology Neurothekeoma Pathology and Forensic Medicine Exon medicine Humans Aged Chromosome Aberrations Neurofibromin 2 Muscle weakness Myxoma Anatomical pathology General Medicine Anatomy Middle Aged medicine.disease Spinal Nerves Spinal nerve Female Schwann cell differentiation medicine.symptom Comparative genomic hybridization |
| Zdroj: | Histopathology. 50:252-257 |
| ISSN: | 1365-2559 0309-0167 |
| DOI: | 10.1111/j.1365-2559.2007.02579.x |
| Popis: | Aims: To report the demographic, clinical and molecular profile of a series of intraspinal nerve sheath myxomas. Nerve sheath myxomas are diagnostically challenging, mainly cutaneous spindle cell neoplasms exhibiting Schwann cell differentiation. They are frequently mistaken for neurothekeomas and their genetic features are essentially unknown. Methods and results: Ten spinal nerve sheath myxomas with a preferential location in the lumbar spine (70%) were investigated. Presenting symptoms consisted of sciatic pain (100%), muscle weakness and paraesthesia (60% each). Intraoperatively, all tumours were attached to a spinal nerve. Chromosomal imbalances by comparative genomic hybridization were found in 8/10 cases, consisting of −22q (80%) and −19 (30%). Polymerase chain reaction analysis of the NF2 gene (exons 1–16) revealed two tumours with mutations in exon 8 and 14, respectively. Conclusions: Although these 10 nerve sheath myxomas exhibited Schwann cell differentiation and frequently showed loss of chromosome 22q typically encountered in peripheral nerve tumours, only two cases demonstrated mutations of the NF2 gene. This may indicate involvement of other tumour suppressor genes on 22q in nerve sheath myxomas and shows that they are more closely related at the molecular level to sporadic schwannomas, underscoring the presumption that they are true nerve sheath tumours. |
| Databáze: | OpenAIRE |
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