Peroxisome Proliferator-Activated Receptors: New Players in the Field of Reproduction
| Autor: | Bettina Toth, Daniela Hornung, Schima Djalali, Christoph Scholz, Udo Jeschke, Klaus Friese |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Infertility
medicine.medical_specialty medicine.medical_treatment Peroxisome Proliferator-Activated Receptors Immunology Receptors Cytoplasmic and Nuclear Peroxisome proliferator-activated receptor Biology Fetal Development Mice Pregnancy Internal medicine Placenta medicine Animals Humans Immunology and Allergy Receptor chemistry.chemical_classification Reproduction Insulin Obstetrics and Gynecology medicine.disease Polycystic ovary Pregnancy Complications Endocrinology medicine.anatomical_structure Reproductive Medicine Nuclear receptor chemistry Female Peroxisome proliferator-activated receptor alpha Insulin Resistance |
| Zdroj: | American Journal of Reproductive Immunology. 58:289-310 |
| ISSN: | 1600-0897 1046-7408 |
| DOI: | 10.1111/j.1600-0897.2007.00514.x |
| Popis: | Peroxisome proliferator-activated receptors (PPAR) are members of the nuclear hormone receptor superfamily. Synthetic ligands to one family member, PPARgamma, are currently widely used as treatment for chronic diseases such as diabetes type II and other insulin resistances, e.g. as seen in polycystic ovary syndrome (PCOS). Moreover, novel approaches employing knock-out mice demonstrated that PPARgamma seems to play a key role in placental and fetal development. This review describes recent insights into the role of PPARs in human reproduction with specific reference to infertility, placental maturation and fetal development as well as disturbed pregnancy. Further, we highlight the current knowledge on synthetic ligands to PPARgamma used as a treatment in women with PCOS. |
| Databáze: | OpenAIRE |
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