Absorption of tetraethylammonium (TEA+) by perfused lobster intestine
| Autor: | Megan C. Piersol, Kenneth M. Sterling, Gregory A. Ahearn |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Organic Cation Transport Proteins
Brush border Physiology Metabolite Absorption chemistry.chemical_compound Serous Membrane Cations Genetics Animals Intestinal Mucosa Molecular Biology Ecology Evolution Behavior and Systematics Homarus Mucous Membrane Tetraethylammonium Organic cation transport proteins Quinine biology Biological Transport Transporter Hydrogen-Ion Concentration biology.organism_classification Intestinal epithelium Nephropidae chemistry Biochemistry Active transport biology.protein Biophysics Animal Science and Zoology |
| Zdroj: | Journal of Experimental Zoology Part A: Ecological Genetics and Physiology. :176-186 |
| ISSN: | 1932-5231 1932-5223 |
| DOI: | 10.1002/jez.a.360 |
| Popis: | The organic cation, tetraethylammonium (TEA+), is actively secreted by mammalian nephrons and crustacean urinary bladders by similar processes in both animal groups. These mechanisms consist of a basolateral Organic Cation Transporter (OCT family) that employs the transmembrane electrical potential as a driving force for organic cation uptake from the blood and a brush border secondary active transport process that exchanges luminal protons for TEA+. The present study examined the nature of 14C-TEA+ transport across the perfused intestinal epithelium of the American lobster, Homarus americanus, to ascertain whether the gut complemented the kidneys in the clearance of these organic metabolites from the blood. Unidirectional mucosa to serosa (M to S) 14C-TEA+ fluxes in anterior and posterior intestine were hyperbolic functions of luminal [TEA+] and significantly (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text