MDM2 Promoter SNP309 Is Associated with Risk of Occurrence and Advanced Lymph Node Metastasis of Nasopharyngeal Carcinoma in Chinese Population
| Autor: | Fuchu He, Xiaojia Dong, Gangqiao Zhou, Yun Zhai, Hao Yang, Kai-tai Yao, Ying Cui, Boqing Qiang, Hongxing Zhang, Ying He, Wei Qiu, Xiumei Zhang, Xiaoai Zhang, Yan Shen, Xiaoyan Yuan, Lianteng Zhi |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Risk Oncology China Cancer Research medicine.medical_specialty Population Logistic regression Polymorphism Single Nucleotide Asian People Internal medicine Epidemiology Genotype Humans Medicine Allele Promoter Regions Genetic education Neoplasm Staging education.field_of_study business.industry Nasopharyngeal Neoplasms Proto-Oncogene Proteins c-mdm2 Odds ratio Middle Aged medicine.disease Confidence interval Nasopharyngeal carcinoma Lymphatic Metastasis Immunology Female business |
| Zdroj: | Clinical Cancer Research. 13:2627-2633 |
| ISSN: | 1557-3265 1078-0432 |
| DOI: | 10.1158/1078-0432.ccr-06-2281 |
| Popis: | Purpose: Mouse double minute 2 (MDM2) is a key negative regulator of the p53 activity. Recently, a polymorphism in the MDM2 intronic promoter, SNP309, was shown to influence MDM2 expression and p53 activity. We examined whether the SNP309 was related to the risk of developing nasopharyngeal carcinoma (NPC) among Chinese populations. Experimental Design: We genotyped the SNP309 in two independent case-control populations in southern China, one is from Guangxi province (including 593 NPC patients and 480 controls) and the other is from Guangdong province (including 239 patients and 286 controls), by PCR direct sequencing. Multivariate logistic regression analysis was used to calculate adjusted odds ratio (OR) and 95% confidence interval (95% CI). Results: We observed that compared with the TT genotype, the genotypes containing G allele (GT + GG genotype) were associated with significant increased susceptibility to NPC in both Guangxi (OR, 1.43; 95% CI, 1.04-1.91) and Guangdong population (OR, 1.53; 95% CI, 1.00-2.36). When these two sample sets were combined, the OR of the GT + GG genotype developing NPC was 1.45 (95% CI, 1.12-1.85) compared with the TT genotype. Furthermore, compared with the TT genotype, the GT + GG genotype was also significantly associated with the advanced lymph node metastasis (OR, 1.84; 95% CI, 1.09-3.05). Conclusions: Our findings suggest that the MDM2 SNP309 may be a risk factor for the occurrence and advanced neck lymph node metastasis of NPC in Chinese population. |
| Databáze: | OpenAIRE |
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