Digital Breast Tomosynthesis and Synthetic 2D Mammography versus Digital Mammography: Evaluation in a Population-based Screening Program
| Autor: | Per Skaane, Christoph I. Lee, Einar Vigeland, Daehoon Park, Jon Lømo, Åsne S Holen, Tone Hovda, Pål Suhrke, Judy Lynn Albertsen, Hilde Bjørndal, Siri Helene Bertelsen Brandal, Randi Gullien, Linda Romundstad, Solveig Hofvind |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Digital mammography Performance measures Radiography Breast Neoplasms Digital breast tomosynthesis 030218 nuclear medicine & medical imaging Cohort Studies 03 medical and health sciences 0302 clinical medicine Breast cancer Image Processing Computer-Assisted Screening programs medicine Humans Mass Screening Mammography Radiology Nuclear Medicine and imaging Medical physics Breast Prospective Studies skin and connective tissue diseases Aged medicine.diagnostic_test Norway business.industry Two-dimensional synthetic mammography Reproducibility of Results Digital Breast Tomosynthesis Middle Aged medicine.disease 030220 oncology & carcinogenesis Female Mammography screening Population screening business |
| Zdroj: | Radiology |
| ISSN: | 1527-1315 0033-8419 |
| Popis: | Purpose: To compare the performance of digital breast tomosynthesis (DBT) and two-dimensional synthetic mammography (SM) with that of digital mammography (DM) in a population-based mammographic screening program. Materials and Methods: In this prospective cohort study, data from 37 185 women screened with DBT and SM and from 61 742 women screened with DM as part of a population-based screening program in 2014 and 2015 were included. Early performance measures, including recall rate due to abnormal mammographic findings, rate of screen-detected breast cancer, positive predictive value of recall, positive predictive value of needle biopsy, histopathologic type, tumor size, tumor grade, lymph node involvement, hormonal status, Ki-67 level, and human epidermal growth factor receptor 2 status were compared in women who underwent DBT and SM screening and in those who underwent DM screening by using x2 tests, two-sample unpaired t tests, and tests of proportions. Results: Recall rates were 3.4% for DBT and SM screening and 3.3% for DM screening (P = .563). DBT and SM screening showed a significantly higher rate of screen-detected cancer compared with DM screening (9.4 vs 6.1 cancers per 1000 patients screened, respectively; P , .001). The rate of detection of tumors 10 mm or smaller was 3.2 per 1000 patients screened with DBT and SM and 1.8 per 1000 patients screened with DM (P , .001), and the rate of grade 1 tumors was 3.3 per 1000 patients screened with DBT and SM versus 1.4 per 1000 patients screened with DM (P , .001). On the basis of immunohistochemical analyses, rates of lymph node involvement and tumor subtypes did not differ between women who underwent DBT and SM screening and those who underwent DM screening. Conclusion: DBT and SM screening increased the detection rate of histologically favorable tumors compared with that attained with DM screening. |
| Databáze: | OpenAIRE |
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