Diagnostic Accuracy of Markers of Insulin Resistance (HOMA-IR) and Insulin Sensitivity (QUICKI) in Gestational Diabetes
| Autor: | Afshan Bibi, Zujaja Hina Haroon, Muhammad Aamir, Athar Iqbal Paracha |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
medicine.medical_specialty endocrine system diseases Cross-sectional study medicine.medical_treatment Gastroenterology Insulin resistance Pregnancy Internal medicine Diabetes mellitus medicine Humans Insulin Glucose tolerance test medicine.diagnostic_test business.industry nutritional and metabolic diseases Gestational age Infant General Medicine Gold standard (test) Glucose Tolerance Test medicine.disease Gestational diabetes Diabetes Gestational Cross-Sectional Studies Female Insulin Resistance business |
| Zdroj: | Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 31(9) |
| ISSN: | 1681-7168 |
| Popis: | OBJECTIVES To determine the diagnostic accuracy of HOMA-IR, and QUICKI in diagnosing gestational diabetes mellitus (GDM) considering oral glucose tolerance test (OGTT) as gold standard. STUDY DESIGN Cross-sectional analytical study. PLACE AND DURATION OF STUDY Department of Chemical Pathology, Armed Forces Institute of Pathology, Rawalpindi from September 2020 to February 2021. METHODOLOGY Pregnant women with gestational age between 24 to 28 weeks, who reported to Endocrine Clinic of AFIP for OGTT, were included in the study. OGTT was performed by following ADA guidelines. Sample for fasting insulin was collected along with first fasting sample of OGTT. HOMA-IR and QUICKI were calculated simultaneously. Percentage was used for qualitative variable while median (IQR 25th-75th) was applied for quantitative variables. OGTT was used as gold standard for calculation of diagnostic accuracy of HOMA-IR and QUICKI. RESULTS Out of 182 patients, 74 (40.6%) were found to have GDM on OGTT while 108 (59.4%) had normal OGTT. Women with GDM (n=74) had median values of fasting insulin 15.9 (IQR 11.2-17.77), HOMA-IR 3.5 (IQR 2.6-4.1) and QUICKI 0.31 (IQR 0.30-0.33) as compared to median values of fasting insulin 8.0 (IQR 5.9-10.3), HOMA-IR 1.60 (IQR 1.12-2.03) and QUICKI 0.35 (IQR 0.34-0.37) in patients (n=108) with normal response to OGTT, (p |
| Databáze: | OpenAIRE |
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