Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity
| Autor: | Katarzyna E. Schewe, Ursula Müller-Vieira, Christina Ries, Matthias Negri, Rolf W. Hartmann, Cornelia M. Grombein, Simon Lucas, Barbara Birk, Ralf Heim |
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| Rok vydání: | 2008 |
| Předmět: |
Aldosterone synthase
Male Cytochrome P-450 CYP1A2 Inhibitors Naphthalenes chemistry.chemical_compound Structure-Activity Relationship Cytochrome P-450 CYP1A2 Drug Discovery Potency Structure–activity relationship Animals Cytochrome P-450 CYP11B2 Humans Isoquinoline Rats Wistar IC50 chemistry.chemical_classification Heart Failure biology Chemistry Myocardium CYP1A2 Fibrosis Rats Enzyme Biochemistry Enzyme inhibitor biology.protein Molecular Medicine |
| Zdroj: | Journal of medicinal chemistry. 51(16) |
| ISSN: | 1520-4804 |
| Popis: | Recently, we reported on the development of potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis. A major drawback of these nonsteroidal compounds was a strong inhibition of the hepatic drug-metabolizing enzyme CYP1A2. In the present study, we examined the influence of substituents in the heterocycle of lead structures with a naphthalene molecular scaffold to overcome this unwanted side effect. With respect to CYP11B2 inhibition, some substituents induced a dramatic increase in inhibitory potency. The methoxyalkyl derivatives 22 and 26 are the most potent CYP11B2 inhibitors up to now (IC50 = 0.2 nM). Most compounds also clearly discriminated between CYP11B2 and CYP11B1, and the CYP1A2 potency significantly decreased in some cases (e.g., isoquinoline derivative 30 displayed only 6% CYP1A2 inhibition at 2 microM concentration). Furthermore, isoquinoline derivative 28 proved to be capable of passing the gastrointestinal tract and reached the general circulation after peroral administration to male Wistar rats. |
| Databáze: | OpenAIRE |
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