Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome
| Autor: | Isabel Pastor, Laura Valeria Iermoli, Elena Pastor, Zulma Manfredi Carabetti, Fabiana Lairion, Marisa G. Repetto, Raúl Francisco Pastor, Alberto Lazarowski, Amalia Merelli, Roberto Héctor Iermoli, Carlos Amadeo Bavasso |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine chronic inflammation Time Factors Neutrophils PIPERINE 030204 cardiovascular system & hematology resveratrol medicine.disease_cause purl.org/becyt/ford/1 [https] chemistry.chemical_compound 0302 clinical medicine Piperidines Hyperlipidemia RESVERATROL METABOLIC SYNDROME Nutrition and Dietetics biology CHRONIC INFLAMMATION ALPHA-TOCOPHEROL Middle Aged C-Reactive Protein Female medicine.symptom lcsh:Nutrition. Foods and food supply medicine.medical_specialty Polyunsaturated Alkamides Inflammation lcsh:TX341-641 Article metabolic syndrome 03 medical and health sciences Alkaloids Oxygen Consumption alpha-tocopherol Diabetes mellitus Internal medicine medicine purl.org/becyt/ford/1.4 [https] Humans Benzodioxoles Aged piperine business.industry C-reactive protein medicine.disease Ferritin Oxidative Stress 030104 developmental biology Endocrinology chemistry Chronic Disease Dietary Supplements Ferritins Luminescent Measurements biology.protein Metabolic syndrome alpha-Tocopherol business Biomarkers Oxidative stress Food Science |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Nutrients Volume 12 Issue 10 Nutrients, Vol 12, Iss 3149, p 3149 (2020) |
| Popis: | Metabolic Syndrome (MetS) is increasing worldwide regardless of culture, genetic, gender, and geographic differences. While multiple individual risk factors, such as obesity, hypertension, diabetes, and hyperlipidemia, can cause cardiovascular disease (CVD), it is the intercurrence of these risk factors that defines MetS as a cluster that creates an environment for atherosclerosis and other manifestations of CVD. Despite the advances in the knowledge and management of each of the components of MetS, there are two molecular biology processes, chronic inflammation and oxidative stress, which are still underdiagnosed and undertreated. In order to assess the effect of a dietary supplement on chronic inflammation in MetS, we conducted a clinical trial with volunteers receiving a formula composed of resveratrol, piperine and alpha tocopherol (FRAMINTROL® ), together with their habitual treatment, for three months. The inflammatory state was evaluated by ultrasensitive C reactive protein (US CRP) and ferritin in plasma, and oxygen consumption and chemiluminescence in neutrophils. The results showed that ferritin decreased by 10% (p < 0.05), US-CRP by 33% (p < 0.0001), oxygen consumption by 55% (p < 0.0001), and spontaneous chemiluminiscence was by 25% (p < 0.005) after treatment. As far as we know, this is the first study showing a chronic inflammation decrease in MetS patients due to the administration of a biopower Resveratrol-piperine and alpha tocopherol dietary supplement together with conventional therapy. |
| Databáze: | OpenAIRE |
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