Effects of a polysaccharide-based multi-ingredient supplement on salivary immunity in non-elite marathon runners

Autor: Roca, Emma, Cantó, Elisabet, Nescolarde, Lexa, Perea, Lidia, Bayés-Genís, Antoni, Sibila, Oriol, Vidal, Silvia, Universitat Autònoma de Barcelona
Přispěvatelé: Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica, Universitat Politècnica de Catalunya. IEB - Instrumentació Electrònica i Biomèdica
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Saliva
Chemokine
Physiology
Biochemistry
Running
0302 clinical medicine
Medicine
Platelet
Nutrition and Dietetics
biology
Enginyeria biomèdica [Àrees temàtiques de la UPC]
Middle Aged
C-Reactive Protein
lipids (amino acids
peptides
and proteins)
lcsh:RC1200-1245
lcsh:Nutrition. Foods and food supply
Research Article
Adult
Bioquímica
Glycans
Marathon
Angiogenin
education
lcsh:TX341-641
Dietary plant-derived polydisperse polysaccharide supplementation
Clinical nutrition
Inflammatory chemokines
Salivary sIgA
03 medical and health sciences
Immune system
Strenuous exercise
Electrònica mèdica
Immunity
Dietary Carbohydrates
Humans
lcsh:Sports medicine
030109 nutrition & dietetics
Innate immune system
business.industry
030229 sport sciences
Immunity
Innate
Medical electronics
Athletes
Dietary Supplements
Immunoglobulin A
Secretory
biology.protein
business
human activities
Biomarkers
Food Science
Zdroj: Recercat. Dipósit de la Recerca de Catalunya
instname
Journal of the International Society of Sports Nutrition
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Journal of the International Society of Sports Nutrition, Vol 16, Iss 1, Pp 1-8 (2019)
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
ISSN: 1550-2783
Popis: Altres ajuts: This study was funded by an unconditional product grant from Mannatech Inc. (Coppell, TX). Extreme exercise may alter the innate immune system. Glycans are involved in several biological processes including immune system regulation. However, limited data regarding the impact of glycan supplementation on immunological parameters after strenuous exercise are available. We aimed to determine the impact of a standardized polysaccharide-based multi-ingredient supplement, Advanced Ambrotose© complex powder (AA) on salivary secretory Immunoglobulin A (sIgA) and pro- and anti-inflammatory protein levels before and after a marathon in non-elite runners. Forty-one male marathon runners who completed the 42.195 km of the 2016 Barcelona marathon were randomly assigned to two study groups. Of them, n = 20 (48%) received the AA supplement for 15 days prior the race (AA group) and n = 21 (52%) did not receive any AA supplement (non-AA group). Saliva and blood samples were collected the day before the marathon and two days after the end of the race. Salivary IgA, pro-inflammatory chemokines (Gro-alpha, Gro-beta, MCP-1) and anti-inflammatory proteins (Angiogenin, ACRP, Siglec 5) were determined using commercially ELISA kits in saliva supernatant. Biochemical parameters, including C-reactive protein, cardiac biomarkers, and blood hemogram were also evaluated. Marathon runners who did not receive the AA supplement experienced a decrease of salivary sIgA and pro-inflammatory chemokines (Gro-alpha and Gro-beta) after the race, while runners with AA supplementation showed lower levels of anti-inflammatory chemokines (Angiogenin). Gro-alpha and Gro-beta salivary levels were lower before the race in the AA group and correlated with blood leukocytes and platelets. Changes in salivary sIgA and inflammatory chemokines, especially Gro-alfa and Gro-beta, were observed in marathon runners supplemented with AA prior to the race. These findings suggested that AA may have a positive effect on immune response after a strenuous exercise.
Databáze: OpenAIRE
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