Iron and Heme Metabolism at the Leishmania–Host Interface
| Autor: | Iqbal Hamza, Maria Fernanda Laranjeira-Silva, José M. Pérez-Victoria |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Iron 030231 tropical medicine Heme macrophage Biology nutritional immunity parasites Article Microbiology Host-Parasite Interactions 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine parasitic diseases medicine Parasite hosting Macrophage Animals Humans Leishmaniasis Leishmania Intracellular parasite porphyrins Anemia medicine.disease biology.organism_classification Heme transport 030104 developmental biology Infectious Diseases chemistry Vector (epidemiology) Parasitology |
| Zdroj: | Trends Parasitol |
| Popis: | Species of the protozoan Leishmania are causative agents of human leishmaniasis, a disease that results in significant death, disability, and disfigurement around the world. The parasite is transmitted to a mammalian host by a sand fly vector where it develops as an intracellular parasite within macrophages. This process requires the acquisition of nutritional iron and heme from the host as Leishmania lacks the capacity for de novo heme synthesis and does not contain cytosolic iron-storage proteins. Proteins involved in Leishmania iron and heme transport and metabolism have been identified and shown to be crucial for the parasite's growth and replication within the host. Consequently, a detailed understanding of how these parasites harness host pathways for survival may lay the foundation for promising new therapeutic intervention against leishmaniasis. |
| Databáze: | OpenAIRE |
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