| Autor: |
Jan J. Molenaar, Louis Chesler, Huib N. Caron, Rogier Versteeg, Robbert J. Kok, Rolf W. Sparidans, Kevin Petrie, Simon P. Robinson, Albert Hallsworth, Yann Jamin, Carel J.M. van Noesel, Ilona J.M. den Hartog, Marli E. Ebus, Evon Poon, M. Emmy M. Dolman |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1078-0432.22454805 |
| Popis: |
Supplementary Tables S1-3. Table S1. IC25/50/75 and LC50 values of AT7519 for MYCN-amplified and non-MYCN-amplified neuroblastoma cell lines and cell seeding densities used to perform MTT cell proliferation assays (96-well plates). IC25/50/75 and LC50 values are derived from dose-response curves. Table S2. In vitro effects on sub-G1 induction and cell cycle progression in MYCN-amplified versus non-MYCN-amplified neuroblastoma cell lines after 72 h treatment with AT7519. Values represent the average percentage of cells in sub-G1, G1, S and G2 +/- SD. Table S3. Pharmacokinetic parameters derived from plasma disappearance and tumour accumulation curves after intraperitoneal administration of AT7519 to mice bearing MYCN-amplified AMC711T neuroblastoma xenografts. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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