Severe Acute Respiratory Syndrome
| Autor: | Po-nin Chan, Kwok-kuen Shing, Ka-Tak Wong, David S.C. Hui, Gavin M. Joynt, Gregory E. Antonio, Nelson Lee, Catherine W. Ho, Florence H. Y. Yap, Anil T. Ahuja, Joseph J.Y. Sung, Wing-hung Ng, Alan Wu |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty media_common.quotation_subject Radiography medicine.medical_treatment Severe Acute Respiratory Syndrome law.invention Pulmonary function testing Hemoglobins Patient Admission law Humans Medicine Radiology Nuclear Medicine and imaging Respiratory system Lung Aged Retrospective Studies media_common Mechanical ventilation L-Lactate Dehydrogenase business.industry Convalescence Age Factors Retrospective cohort study Middle Aged Respiration Artificial Intensive care unit Respiratory Function Tests Surgery Intensive Care Units medicine.anatomical_structure Pulmonary Diffusing Capacity Female Radiology Tomography X-Ray Computed business Follow-Up Studies |
| Zdroj: | Journal of Computer Assisted Tomography. 28:790-795 |
| ISSN: | 0363-8715 |
| DOI: | 10.1097/00004728-200411000-00010 |
| Popis: | Objective: To evaluate thin-section computed tomography findings of patients with severe acute respiratory syndrome (SARS) in the convalescent period and to correlate the results with clinical parameters and lung functiontests. Methods: Ninety-nine severe acute respiratory syndrome patients with persistent changes on follow-up chest radiography were included. One hundred seventy computed tomography examinations at baseline (n = 70), 3 months (n = 56), and 6 months (n = 44) were retrospectively evaluated to determine the extent of ground-glass opacification, reticulation, and total parenchymal involvement. Patients' demographic information, clinical information during treatment, and results of lung function tests at 3 and 6 months were correlated with computed tomography findings. Results: A significant serial improvement in the extent of overall ground-glass opacification, overall reticulation, and total parenchymal involvement was observed (P < 0.01). Advanced age, previous intensive care unit admission, mechanical ventilation, alternative treatment, higher peak lactate dehydrogenase, and peak radiographic involvement during treatment showed a positive correlation with overall reticulation and total parenchymal involvement at 6 months. There was a significant negative correlation between overall reticulation and total parenchymal involvement with diffusion capacity adjusted for hemoglobin at 3 and 6 months (P < 0.01). Conclusion: Lung changes on thin-section computed tomography of severe acute respiratory syndrome patients improved with time during the convalescent period and showed a significant correlation with advanced age, parameters indicating severe illness, and diffusion capacity adjusted for hemoglobin on follow-up. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|