Relationship BetweenSDF-1G801APolymorphism and its Expression in Tunisian Patients with Colorectal Cancer
| Autor: | Abdelmajid Ben Hmida, Sabeh Mzabi, Saadia Bouraoui, Sameh Amara, Donia Ounissi, Meriem Khiari, Ines Chaar |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Pathology Tunisia Adolescent Colorectal cancer Clinical Biochemistry Immunology Population Stage ii Biology Polymorphism Single Nucleotide Young Adult Internal medicine Genotype medicine Humans Immunology and Allergy Genetic Predisposition to Disease Allele education Aged Aged 80 and over education.field_of_study Middle Aged medicine.disease Primary tumor Chemokine CXCL12 Medical Laboratory Technology Cohort Immunohistochemistry Female Colorectal Neoplasms |
| Zdroj: | Journal of Immunoassay and Immunochemistry. 36:182-194 |
| ISSN: | 1532-4230 1532-1819 |
| DOI: | 10.1080/15321819.2014.917428 |
| Popis: | The aim was to evaluate the relationship between SDF-1G801A polymorphism and its immunohistochemical expression in colorectal cancer tissues in the Tunisian cohort. The molecular and immunohistochemical analysis showed that SDF-1G801A polymorphic variant was higher in CRC patients with TNM stage II and III, the SDF-1 expression was significantly increased from normal mucosa to primary tumor (p < 0.05). CRC patients have higher frequency of A allele (52.01%) than controls (26.8%) (P = 0.0001). Thus, SDF-1 polymorphism is a risk factor of colorectal cancer susceptibility in our population, the polymorph genotype of SDF-1 maybe associated with clinical manifestations in CRC patients in Tunisia. |
| Databáze: | OpenAIRE |
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