Effects of intravenous Escherichia coli dose on the pathophysiological response of colostrum-fed Jersey calves
| Autor: | M.A. Ballou, C.J. Cobb, L.E. Hulbert, Jeffery A. Carroll |
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| Rok vydání: | 2011 |
| Předmět: |
Isotonic saline
Immunology Dose dependence Cattle Diseases Physiology Biology medicine.disease_cause Article Leukocyte Count Bolus (medicine) Sepsis Leukocytes medicine Animals Escherichia coli Escherichia coli Infections Haptoglobins General Veterinary Colostrum Inflammatory response Septicemia Rectal temperature Pathophysiology Peripheral blood Calf Cytokines Cattle |
| Zdroj: | Veterinary Immunology and Immunopathology |
| ISSN: | 0165-2427 |
| DOI: | 10.1016/j.vetimm.2011.02.008 |
| Popis: | Objectives of the present study were to characterize the dose dependency of an intravenous Escherichia coli O111:H8 challenge in colostrum-fed Jersey calves and to identify any biochemical markers indicative of septicemia. Eighteen 3-week old colostrum-fed Jersey calves were completely randomized to 1 of 6 doses of E. coli O111:H8. The challenge doses included 0, 1.5 × 105, 1.5 × 106, 1.5 × 107, 1.5 × 108, and 1.5 × 109 colony-forming units (CFU) given intravenously as a bolus in 5 mL of sterile isotonic saline. Peripheral blood samples were collected at 0, 2, 4, 8, 12, 24, and 48 h relative to the challenge for biochemical, total leukocyte count, and differential analyses. Rectal temperatures were collected via indwelling rectal temperature probes at 5-min intervals, and hourly averages calculated from 2 d prior to the challenge till 2 d after the challenge. All calves survived the 48 h observation period following the challenge. Calves given 1.5 × 108 and 1.5 × 109 CFU displayed sickness behaviors (P |
| Databáze: | OpenAIRE |
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