Photodynamic therapy of nodular basal cell carcinoma with multifiber contact light delivery
| Autor: | J Kapostins, Katarina Svanberg, Sara Pålsson, Marcelo Soto Thompson, Niels Bendsoe, J Spigulis, Thomas Johansson, A Derjabo, Sune Svanberg, Stefan Andersson-Engels, U Stenram |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Skin Neoplasms Health Toxicology and Mutagenesis medicine.medical_treatment Nodular basal cell carcinoma Protoporphyrins Photodynamic therapy Toxicology Light delivery Fluorescence Pathology and Forensic Medicine chemistry.chemical_compound Carcinoma medicine Humans Complete response Aged Photosensitizing Agents Protoporphyrin IX business.industry Lasers General Medicine Aminolevulinic Acid Middle Aged medicine.disease Treatment efficacy General purpose chemistry Photochemotherapy Carcinoma Basal Cell Female business Nuclear medicine |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0731-8898 |
| Popis: | To overcome the limited treatment depth of superficial photodynamic therapy we investigate interstitial light delivery. In the present work the treatment light was delivered using a system in which three or six clear-cut fibers were placed in direct contact with the tumor area. This placement was thought to represent a step toward general purpose interstitial PDT. Twelve nodular basal cell carcinomas were treated employing delta-aminolevulinic acid and 635 nm laser irradiation. Fluorescence measurements were performed monitoring the buildup and subsequent bleaching of the produced sensitizer protoporphyrin IX. The treatment efficacy, judged at a 28-month follow-up, showed a 100% complete response. Two punch excisions at 7 months converted two partial responses to complete responses. One patient failed to appear at all follow-up sessions. The outcome of the treatments was comparable to superficial photodynamic therapy in terms of histological, clinical, and cosmetic results. |
| Databáze: | OpenAIRE |
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