Preoperative QTc Interval is Not Associated With Intraoperative Cardiac Events or Mortality in Liver Transplantation Patients
| Autor: | Samuel DeMaria, Carlyle Hamsher, Bryan Hill, Hung-Mo Lin, Sang Kim, Menachem M. Weiner, Jeron Zerillo, Thomas T. Joseph, Jiawen Li, Chang Park, Devon Flaherty |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment 030204 cardiovascular system & hematology Liver transplantation QT interval Cohort Studies Electrocardiography 03 medical and health sciences Liver disease 0302 clinical medicine 030202 anesthesiology Internal medicine Preoperative Care medicine Humans Hospital Mortality cardiovascular diseases Intraoperative Complications Aged Retrospective Studies business.industry Medical record Incidence (epidemiology) Retrospective cohort study Middle Aged medicine.disease Liver Transplantation Long QT Syndrome Anesthesiology and Pain Medicine Platelet transfusion cardiovascular system Cardiology Female Fresh frozen plasma Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Cardiothoracic and Vascular Anesthesia. 33:961-966 |
| ISSN: | 1053-0770 |
| DOI: | 10.1053/j.jvca.2018.06.002 |
| Popis: | Objectives The primary objective of this study was to determine whether liver transplantation recipients with preoperative prolonged corrected (QTc) intervals have a higher incidence of intraoperative cardiac events and/or postoperative mortality compared with their peers with normal QTc intervals. Design This was a retrospective cohort study. Setting Single academic hospital in New York, NY. Participants Patients undergoing liver transplantation between 2007 and 2016. Interventions None. Measurements and Main Results Data relating to all liver transplantation recipients with preoperative electrocardiograms were queried from an institutional anesthesia data warehouse and electronic medical records. Primary outcomes were a composite outcome of intraoperative cardiac events and postoperative mortality. Patients with a prolonged QTc interval (>450 ms for men, >470 ms for women) did not demonstrate an association with intraoperative cardiac events, 30- or 90-day mortality, in-hospital mortality, or overall mortality compared with recipients in the normal QTc interval group. A prolonged QTc was found to be associated with increased anesthesia time, surgical time, length of hospital stay, and incidence of fresh frozen plasma and platelets transfusion. Conclusions Prolonged QTc interval is not associated with an increased incidence of intraoperative cardiac events or mortality in liver transplantation recipients. The demonstrated correlation among QTc length and Model for End-stage Liver Disease score, blood component requirements, surgical and anesthetic times, and hospital length of stay likely represents the association between QTc length and severity of liver disease. |
| Databáze: | OpenAIRE |
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