Crystal Structure of Novel Terephthalate Salt of Antiarrhythmic Drug Disopyramide
| Autor: | Kaori Fukuzawa, Majid I. Tamboli, Etsuo Yonemochi, Takayuki Furuishi, Yohei Utusmi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Terephthalic acid
crystal structure General Chemical Engineering Protonation 02 engineering and technology Crystal structure Triclinic crystal system 010402 general chemistry 01 natural sciences slurry crystallization law.invention Inorganic Chemistry chemistry.chemical_compound molecular packing law lcsh:QD901-999 Molecule salt General Materials Science Crystallization Fourier transform infrared spectroscopy Hydrogen bond 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Crystallography chemistry lcsh:Crystallography 0210 nano-technology Disopyramide |
| Zdroj: | Crystals, Vol 11, Iss 368, p 368 (2021) Crystals Volume 11 Issue 4 |
| ISSN: | 2073-4352 |
| Popis: | 1:1 salt of Disopyramide (DPA) with Terephthalic acid (TA) was obtained by the slow solvent evaporation and the slurry crystallization methods. X-ray single crystal diffraction of DPA:TA confirmed the formation of salt by the transfer of an acidic proton from one of the carboxylic acidic groups of TA to the tertiary amino group of the chain moiety (N3-nitrogen atom) of the DPA molecules. DPA:TA salt crystals crystalize in the triclinic system with space group P-1. The asymmetric unit, comprising one protonated DPA and one TA anion, are linked by a strong charge assisted N+–H∙∙∙O¯ hydrogen bond and a C–H∙∙∙O¯ hydrogen bond. Moreover, structural characterization of DPA:TA salt was carried out using Fourier transform infrared spectroscopy, differential scanning calorimeter, thermogravimetric analysis, and powder X-ray diffraction techniques |
| Databáze: | OpenAIRE |
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