Parametrial involvement in endometrial carcinomas: its incidence and correlation with other histological parameters
| Autor: | Masafumi Koshiyama, Shigeo Yura, Yasuichiro Yura, Ikuo Konishi, Masumi Yoshida, Michiharu Hayashi, Katsuko Matsushita, Takahide Mori, Kunihiko Tauchi |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Pathology Connective tissue Endometrium Metastasis medicine Parametrium Humans Neoplasm Invasiveness Stage (cooking) Aged Neoplasm Staging business.industry Parametrial Carcinoma Uterus Obstetrics and Gynecology Middle Aged medicine.disease Prognosis Survival Analysis Endometrial Neoplasms medicine.anatomical_structure Lymphatic system Oncology Multivariate Analysis Histopathology Female business |
| Zdroj: | Gynecologic oncology. 63(1) |
| ISSN: | 0090-8258 |
| Popis: | To identify the incidence and spread pattern of parametrial involvement in endometrial carcinomas, resected parametria in 91 patients who underwent radical or modified radical hysterectomy with pelvic lymphadenectomy were histologically examined. The relationship between parametrial involvement and other histopathological features including histological type, tumor grade, depth of myometrial invasion, lymph-vascular space invasion, cervical involvement, adnexal metastasis, and lymph node metastasis was studied. Parametrial involvement was histologically demonstrated in 12 (13.2%) of the 91 cases. There were 2 patterns of spread: direct invasion of cancer cells to the parametrial connective tissue (5 cases) and lymphatic involvement within the parametrium (7 cases). According to the FIGO surgical stage, parametrial involvement was found in none (0%) of 48 patients in Stage I, 3 (11.5%) of 26 in Stage II, and 9 (52.9%) of 17 in Stage III. Among histopathological variables, the presence of parametrial involvement was significantly correlated with deep myometrial invasion and lymph-vascular space invasion in the myometrium. Multivariate analysis revealed that parametrial involvement significantly contributed to the poor prognosis in Stage II and III patients. |
| Databáze: | OpenAIRE |
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