Combining Understanding of Immunological Mechanisms and Genetic Variants Toward Development of Personalized Medicine for Psoriasis Patients
| Autor: | Caroline Lin Lin Chua, Natalie Vivien Gunter, Wei Hsum Yap, Bryan Ju Min Yap |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
lcsh:QH426-470 Mini Review Single-nucleotide polymorphism Genomics Disease Computational biology 03 medical and health sciences 0302 clinical medicine Psoriasis Genetic predisposition Genetics genome-wide association studies (GWAS) Medicine Genotyping Genetics (clinical) Genetic association business.industry psoriasis personalized medicine medicine.disease susceptibility loci lcsh:Genetics 030104 developmental biology 030220 oncology & carcinogenesis Molecular Medicine Personalized medicine business autoimmune disorder |
| Zdroj: | Frontiers in Genetics, Vol 10 (2019) Frontiers in Genetics |
| ISSN: | 1664-8021 |
| Popis: | Psoriasis is multifactorial disease with complex genetic predisposition. Recent advances in genetics and genomics analyses have provided many insights into the relationship between specific genetic predisposition and the immunopathological mechanisms driving psoriasis manifestation. Novel approaches which utilize array-based genotyping technologies such as genome-wide association studies and bioinformatics tools for transcriptomics analysis have identified single nucleotide polymorphisms, genes and pathways that are associated with psoriasis. The discovery of these psoriasis-associated susceptibility loci, autoimmune targets and altered signaling pathways have provided opportunities to bridge the gap of knowledge from sequence to consequence, allowing new therapeutic strategies for the treatment of psoriasis to be developed. Here, we discuss recent advances in the field by highlighting how immune functions associated with psoriasis susceptibility loci may contribute to disease pathogenesis in different populations. Understanding the genetic variations in psoriasis and how these may influence the immunological pathways to cause disease will contribute to the efforts in developing novel and targeted personalized therapies for psoriasis patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|