Parkinson’s Disease and Autophagy
| Autor: | Berta Claramonte-Clausell, Juan Vicente Sánchez-Andrés, Maria Herrero, Ana María Sánchez-Pérez |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Parkinson's disease
business.industry Autophagy Neurodegeneration Neuroscience (miscellaneous) Review Article Disease Protein aggregation medicine.disease Bioinformatics Neuroprotection lcsh:RC346-429 Psychiatry and Mental health Medicine Neurology (clinical) business lcsh:Neurology. Diseases of the nervous system Therapeutic strategy |
| Zdroj: | Repositori Universitat Jaume I Universitat Jaume I Parkinson's Disease Parkinson's Disease, Vol 2012 (2012) |
| ISSN: | 2042-0080 2090-8083 |
| DOI: | 10.1155/2012/429524 |
| Popis: | It is generally accepted that a correlation between neurodegenerative disease and protein aggregation in the brain exists; however, a causal relationship has not been elucidated. In neurons, failure of autophagy may result in the accumulation of aggregate-prone proteins and subsequent neurodegeneration. Thus, pharmacological induction of autophagy to enhance the clearance of intracytoplasmic aggregate-prone proteins has been considered as a therapeutic strategy to ameliorate pathology in cell and animal models of neurodegenerative disorders. However, autophagy has also been found to be a factor in the onset of these diseases, which raises the question of whether autophagy induction is an effective therapeutic strategy, or, on the contrary, can result in cell death. In this paper, we will first describe the autophagic machinery, and we will consider the literature to discuss the neuroprotective effects of autophagy. |
| Databáze: | OpenAIRE |
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