Epilepsy Research in Mali: A Pilot Pharmacokinetics Study on First-Line Antiepileptic Drug Treatment
| Autor: | Sekou Bah, Karim Traore, Gordon A. Awandare, Seidina A.S. Diakité, Housseini Dolo, Fatoumata Doumbia, Drissa Traore, Youssoufa Maiga, Mahamadou Diakite, Souleymane Coulibaly, Aboucacar Alassane Oumar, Seydou Doumbia, Adama Karembe, Modibo Sangare, Modibo Kouyate, Oumar Sidibe, S Coulibaly, Hyung-Goo Kim, Amadou Diawara, Arouna Togora, Callixte Kuate, Mohamed S Haidara |
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| Rok vydání: | 2020 |
| Předmět: |
Quality of life
Pediatrics medicine.medical_specialty Mali 050105 experimental psychology 03 medical and health sciences Epilepsy 0302 clinical medicine Pharmacokinetics Valproic acid Medicine 0501 psychology and cognitive sciences Young adult Valproic Acid business.industry 05 social sciences Carbamazepine medicine.disease Phenobarbital Original Article business Developed country 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Epilepsy Research |
| ISSN: | 2233-6257 2233-6249 |
| Popis: | Background and Purpose The indication and benefit of plasma level of antiepileptic (AEDs) has been debating in the monitoring of people living with epilepsy and the epilepsy treatment gap has largely been documented in developed countries. This study was aimed to highlight the epilepsy treatment gap between rural and urban Mali. Methods We conducted a pilot study on AEDs treatment from September 2016 to May 2019. For 6 months, 120 children and young adults living with epilepsy (rural site, 90; urban site, 30) received phenobarbital, valproic acid and/or carbamazepine. At our rural study site, we determined the AED plasma levels, monitored the frequency, severity and the duration of seizure, and administered monthly the McGill quality of life questionnaire. At our urban study site, each patient underwent an electroencephalogram and brain computed tomography scan without close monitoring. Results At the rural study site, patients were mostly on monotherapy; AED levels at 1 month (M1) (n=90) and at 3 months (M3) (n=27) after inclusion were normal in 50% at M1 versus 55.6% at M3, low in 42.2% at M1 versus 33.3% at M3 and high in 7.8% at M1 versus 11.1% at M3. AED levels at M1 and at M3 were significantly different p |
| Databáze: | OpenAIRE |
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