Apelin peptides block the entry of human immunodeficiency virus (HIV)

Autor:	Yasushi Soda, Hiroo Hoshino, Yuji Haraguchi, Min-Xu Zou, Hui-Yu Liu, Kazuhiko Tatemoto
Rok vydání:	2000
Předmět:	Receptors CXCR4 Virus genetics Receptors CCR5 viruses Molecular Sequence Data Biophysics Human immunodeficiency virus (HIV) Biology Ligands medicine.disease_cause Giant Cells Biochemistry Receptors G-Protein-Coupled Inhibitory Concentration 50 Structural Biology Tumor Cells Cultured Genetics medicine Humans Inhibitory concentration 50 Amino Acid Sequence Receptor Molecular Biology Peptide sequence Apelin receptor Apelin Receptors Receptors Dopamine D2 Human immunodeficiency virus Simian immunodeficiency virus Brain virus diseases RNA-Directed DNA Polymerase Glioma Cell Biology Virology HIV Reverse Transcriptase Peptide Fragments Apelin CD4 Antigens HIV-2 APJ HIV-1 Intercellular Signaling Peptides and Proteins Receptors Virus Chemokines Carrier Proteins Coreceptor
Zdroj:	FEBS Letters. 473:15-18
ISSN:	0014-5793
Popis:	The orphan G protein-coupled receptor APJ has been shown to be a coreceptor for human and simian immunodeficiency virus (HIV and SIV) strains. We have determined that some HIV and SIV strains use APJ as a coreceptor to infect the brain-derived NP-2/CD4 cells. Because apelin is an endogenous ligand for the APJ receptor, we examined the inhibitory effects of apelin peptides on HIV infection, and found that the apelin peptides inhibit the entry of some HIV-1 and HIV-2 into the NP-2/CD4 cells expressing APJ. The inhibitory efficiency has been found to be in the order of apelin-36>apelin-17>apelin-13>apelin-12.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59dd0edc3344b98f7eff564248fd6895 https://doi.org/10.1016/s0014-5793(00)01487-3 Zobrazit plný text záznamu Plný text