The nociceptin/orphanin FQ/NOP receptor system as a target for treatment of alcohol abuse: a review of recent work in alcohol-preferring rats
| Autor: | Roberto Ciccocioppo, Amalia Fedeli, Maurizio Massi, Daina Economidou |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Alcohol Drinking
medicine.drug_class Conditioning Classical NOP Alcohol abuse Experimental and Cognitive Psychology Pharmacology Social Environment Nociceptin Receptor Mice Behavioral Neuroscience chemistry.chemical_compound medicine Animals Humans Receptor Injections Intraventricular Motivation Ethanol Morphine Chemistry Ventral Tegmental Area Association Learning Receptor antagonist medicine.disease Peptide Fragments Conditioned place preference Rats Alcoholism Nociceptin receptor Opioid Peptides Receptors Opioid Morphine Dependence Neuroscience Stress Psychological Alcohol Deterrents medicine.drug |
| Zdroj: | Physiology & Behavior. 79:121-128 |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/s0031-9384(03)00112-4 |
| Popis: | The intracerebroventricular administration of the 17 aminoacid peptide nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of the NOP receptor (previously referred to as ORL-1 or OP4 receptor), reduces voluntary 10% ethanol intake in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats. Studies aimed at the pharmacological characterization of the receptor, which mediates the effect, have shown that the C-terminal 13 aminoacid sequence is crucial for activity and that the selective NOP receptor antagonist [Nphe1]N/OFQ(1–13)NH2 blocks the effect of N/OFQ on ethanol drinking. In place conditioning studies, N/OFQ abolishes the conditioned place preference (CPP) induced by ethanol in msP rats, or by morphine in nonselected Wistar rats; these findings suggest that N/OFQ is able to abolish the rewarding properties of ethanol and morphine. Moreover, N/OFQ inhibits reinstatement of alcohol-seeking behavior induced to electric footshock stress, as well as reinstatement of alcohol-seeking behavior induced by ethanol-paired cues. Together, these findings suggest that N/OFQ and its receptor may represent an interesting target for pharmacological treatment of alcohol abuse. |
| Databáze: | OpenAIRE |
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