The indications for hepatectomy for multinodular hepatocellular carcinoma: experience from a single institution
| Autor: | Qiang Li, Yun long Cui, Hui Kai Li, Ti Zhang, Yuan Da Zhou |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Multivariate analysis Carcinoma Hepatocellular Adolescent medicine.medical_treatment Gastroenterology Young Adult Postoperative Complications Internal medicine medicine Hepatectomy Humans Hospital Mortality Aged Retrospective Studies Univariate analysis business.industry Proportional hazards model Mortality rate Liver Neoplasms Perioperative Middle Aged medicine.disease Survival Analysis Treatment Outcome Hepatocellular carcinoma Multivariate Analysis Surgery Female Liver function business |
| Zdroj: | Digestive surgery. 32(2) |
| ISSN: | 1421-9883 |
| Popis: | Aims: This study was conducted in order to investigate the indications for hepatecomy for multinodular hepatocellular carcinoma (MNHCC) in single institution. Methods: We retrospectively analyzed the medical records from 55 MNHCC patients, mainly with Child-Pugh A liver function, who underwent hepatectomy from January 2006 to December 2008. Both short- and long-term outcomes were analyzed. In addition, the prognostic significance of clinicopathological factors on overall survival (OS) was investigated by univariate analysis using the log-rank test. A Cox proportional hazards model was used in a subsequent multivariate analysis. Results: The perioperative morbidity rate (grade II or higher) was 18.2% (n = 10), and the in-hospital mortality rate was 3.6%. The median OS was 23.9 months (range, 2.5-84 months), whereas the median disease-free survival was 8.75 months (range, 1-65 months). Independent prognostic risk factors of 5-year OS included the number of tumors >2 (p = 0.032) and gross morphology indicating multiple tumor nodules scattered throughout the liver (p = 0.009). Conclusions: The postoperative morbidity and mortality rates were acceptable. The number of tumors >2 and gross morphology indicating multiple tumor nodules scattered throughout the liver were independent prognostic risk factors for patients with MNHCC after hepatectomy. Patients with both of these features had a very poor prognosis and were not considered suitable for surgery. |
| Databáze: | OpenAIRE |
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