Selective stimulation of the ferret abdominal vagus nerve with multi-contact nerve cuff electrodes
| Autor: | Lee E. Fisher, Liane Wong, Bryan McLaughlin, Charles C. Horn, Jonathan A. Shulgach, Michael Sciullo, Derek M. Miller, Ameya C. Nanivadekar, Bill J. Yates, Dylan W. Beam, John I. Ogren, Stephanie Fulton |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Vagus Nerve Stimulation medicine.medical_treatment Science Stimulation Nerve conduction velocity Article 03 medical and health sciences 0302 clinical medicine medicine Animals Autonomic nervous system Electrodes Evoked Potentials Neurons Multidisciplinary business.industry Ferrets Nodose Ganglion Vagus Nerve Multielectrode array Anatomy Gastrointestinal system Vagus nerve Ganglion Gastrointestinal Tract 030104 developmental biology medicine.anatomical_structure Preclinical research Cuff Medicine business Biomedical engineering 030217 neurology & neurosurgery Vagus nerve stimulation |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Dysfunction and diseases of the gastrointestinal (GI) tract are a major driver of medical care. The vagus nerve innervates and controls multiple organs of the GI tract and vagus nerve stimulation (VNS) could provide a means for affecting GI function and treating disease. However, the vagus nerve also innervates many other organs throughout the body, and off-target effects of VNS could cause major side effects such as changes in blood pressure. In this study, we aimed to achieve selective stimulation of populations of vagal afferents using a multi-contact cuff electrode wrapped around the abdominal trunks of the vagus nerve. Four-contact nerve cuff electrodes were implanted around the dorsal (N = 3) or ventral (N = 3) abdominal vagus nerve in six ferrets, and the response to stimulation was measured via a 32-channel microelectrode array (MEA) inserted into the left or right nodose ganglion. Selectivity was characterized by the ability to evoke responses in MEA channels through one bipolar pair of cuff contacts but not through the other bipolar pair. We demonstrated that it was possible to selectively activate subpopulations of vagal neurons using abdominal VNS. Additionally, we quantified the conduction velocity of evoked responses to determine what types of nerve fibers (i.e., Aδ vs. C) responded to stimulation. We also quantified the spatial organization of evoked responses in the nodose MEA to determine if there is somatotopic organization of the neurons in that ganglion. Finally, we demonstrated in a separate set of three ferrets that stimulation of the abdominal vagus via a four-contact cuff could selectively alter gastric myoelectric activity, suggesting that abdominal VNS can potentially be used to control GI function. |
| Databáze: | OpenAIRE |
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