J-waves in acute COVID-19: A novel disease characteristic and predictor of mortality?

Autor: Timur Ilgamovich Musin, Marat Rifkatovich Badykov, Peter Jirak, Anton Viktorovich Tyurin, Dinar Enikeev, Benzhi Cai, P. A. Davtyan, Zilya Adibovna Bagmanova, Kristen Kopp, Ruslan Mansurovich Gumerov, Halima Malikovna Talipova, Damir Gareev, Uta C. Hoppe, Rudin Pistulli, Lukas J. Motloch, Diana Firdavisovna Gareeva, Valentin Pavlov, Naufal Shamilevich Zagidullin, I. A. Lakman
Rok vydání: 2021
Předmět:
Male
Viral Diseases
Pulmonology
Epidemiology
Electrocardiography
Medical Conditions
Medicine and Health Sciences
Stroke
Multidisciplinary
medicine.diagnostic_test
Mortality rate
Incidence (epidemiology)
Middle Aged
Prognosis
Infectious Diseases
Bioassays and Physiological Analysis
Cohort
Medicine
Female
Arrhythmia
Research Article
medicine.medical_specialty
Death Rates
Science
Cardiology
Research and Analysis Methods
Population Metrics
Internal medicine
medicine
Humans
cardiovascular diseases
Pandemics
Aged
Retrospective Studies
Heart Failure
Population Biology
business.industry
Proportional hazards model
Electrophysiological Techniques
Biology and Life Sciences
COVID-19
Covid 19
Arrhythmias
Cardiac
Retrospective cohort study
Pneumonia
medicine.disease
Heart failure
Tachycardia
Ventricular
Cardiac Electrophysiology
business
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0257982 (2021)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0257982
Popis: Background J-waves represent a common finding in routine ECGs (5–6%) and are closely linked to ventricular tachycardias. While arrhythmias and non-specific ECG alterations are a frequent finding in COVID-19, an analysis of J-wave incidence in acute COVID-19 is lacking. Methods A total of 386 patients consecutively, hospitalized due to acute COVID-19 pneumonia were included in this retrospective analysis. Admission ECGs were analyzed, screened for J-waves and correlated to clinical characteristics and 28-day mortality. Results J-waves were present in 12.2% of patients. Factors associated with the presence of J-waves were old age, female sex, a history of stroke and/or heart failure, high CRP levels as well as a high BMI. Mortality rates were significantly higher in patients with J-waves in the admission ECG compared to the non-J-wave cohort (J-wave: 14.9% vs. non-J-wave 3.8%, p = 0.001). After adjusting for confounders using a multivariable cox regression model, the incidence of J-waves was an independent predictor of mortality at 28-days (OR 2.76 95% CI: 1.15–6.63; p = 0.023). J-waves disappeared or declined in 36.4% of COVID-19 survivors with available ECGs for 6–8 months follow-up. Conclusion J-waves are frequently and often transiently found in the admission ECG of patients hospitalized with acute COVID-19. Furthermore, they seem to be an independent predictor of 28-day mortality.
Databáze: OpenAIRE
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