Effect of Dietary Bioactive Compounds on Mitochondrial and Metabolic Flexibility
| Autor: | Meritxell Martín-Gari, Ana Belén Granado-Serrano, Anna Cassanyé, Manuel Portero-Otin, José C. E. Serrano |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Polyphenol Ácidos omega-3 lcsh:Medicine Context (language use) Review Oxidative phosphorylation 030204 cardiovascular system & hematology Mitochondrion Biology Àcids grassos omega-3 Mitocondris 03 medical and health sciences 0302 clinical medicine Insulin resistance insulin resistance medicine Fibra alimentària Omega-3 fatty acids Fiber Inner mitochondrial membrane polyphenols lcsh:R Polyphenols Metabolism medicine.disease Metabolisme Mitochondria Fiber in human nutrition mitochondria 030104 developmental biology Biochemistry Mitochondrial biogenesis Polifenols ω-3 metabolism Function (biology) fiber |
| Zdroj: | Diseases, Vol 4, Iss 1, p 14 (2016) Repositorio Abierto de la UdL Universitad de Lleida Recercat. Dipósit de la Recerca de Catalunya instname Diseases |
| ISSN: | 2079-9721 |
| Popis: | Metabolic flexibility is the capacity of an organism to adequately respond to changes in the environment, such as nutritional input, energetic demand, etc. An important player in the capacity of adaptation through different stages of metabolic demands is the mitochondrion. In this context, mitochondrial dysfunction has been attributed to be the onset and center of many chronic diseases, which are denoted by an inability to adapt fuel preferences and induce mitochondrial morphological changes to respond to metabolic demands, such as mitochondrial number, structure and function. Several nutritional interventions have shown the capacity to induce changes in mitochondrial biogenesis/degradation, oxidative phosphorylation efficiency, mitochondrial membrane composition, electron transfer chain capacity, etc., in metabolic inflexibility states that may open new target options and mechanisms of action of bioactive compounds for the treatment of metabolic diseases. This review is focused in three well-recognized food bioactive compounds that modulate insulin sensitivity, polyphenols, ω-3 fatty acids and dietary fiber, by several mechanism of action, like caloric restriction properties and inflammatory environment modulation, both closely related to mitochondrial function and dynamics. |
| Databáze: | OpenAIRE |
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