Inhibition of bacterial growth and galactosyltransferase activity of WbwC by α, ω-bis(3-alkyl-1H-imidazolium)alkane salts: Effect of varying carbon content
| Autor: | Jason Z. Vlahakis, Jacob Melamed, Alexander Kocev, Inka Brockhausen, Yaozu Xu, Shuo Wang, Xianqi Kong, Walter A. Szarek |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Clinical Biochemistry
Pharmaceutical Science Bacterial growth Gram-Positive Bacteria 01 natural sciences Biochemistry Medicinal chemistry Structure-Activity Relationship Gram-Negative Bacteria Drug Discovery Humans Molecular Biology Cells Cultured Alkyl Cell Proliferation chemistry.chemical_classification Galactosyltransferase Alkane Dose-Response Relationship Drug Molecular Structure biology 010405 organic chemistry Chemistry Cell growth Escherichia coli Proteins Organic Chemistry Imidazoles Galactosyltransferases Antimicrobial biology.organism_classification Anti-Bacterial Agents 0104 chemical sciences 010404 medicinal & biomolecular chemistry Enzyme Molecular Medicine Salts Bacteria |
| Zdroj: | Bioorganic & Medicinal Chemistry. 28:115494 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/j.bmc.2020.115494 |
| Popis: | A series of compounds was designed and synthesized having two imidazolium rings separated by a polymethylene spacer and having alkyl substituents on each of the imidazolium rings. The compounds were assayed for their effects on the activity of galactosyltransferase WbwC, and also on the growth of Gram-negative and Gram-positive bacteria, as well as human cells. The inhibition observed on enzyme activities and cell growth was dependent on the total number of carbons in the spacer and the alkyl substituents on the imidazolium rings. These readily synthesized, achiral compounds have potential as antimicrobial and antiseptic agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect