Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework
Autor: | Tock H. Chua, Angus Cook, Gael Davidson, Philip Weinstein, Peter Speldewinde |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Entomology
lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 030231 tropical medicine Biodiversity Review Biology Macaque lcsh:Infectious and parasitic diseases law.invention 03 medical and health sciences 0302 clinical medicine law Borneo biology.animal Zoonoses parasitic diseases medicine Disease Transmission Infectious Animals Humans lcsh:RC109-216 Plasmodium knowlesi 030212 general & internal medicine Ecosystem Ecology Macaca nemestrina Zoonotic Anthropogenic land use change Primate Diseases medicine.disease biology.organism_classification Malaria Macaca fascicularis Infectious Diseases Transmission (mechanics) Parasitology |
Zdroj: | Malaria Journal Malaria Journal, Vol 18, Iss 1, Pp 1-13 (2019) |
ISSN: | 1475-2875 |
Popis: | Plasmodium knowlesi is a zoonotic malaria parasite normally residing in long-tailed and pig-tailed macaques (Macaca fascicularis and Macaca nemestrina, respectively) found throughout Southeast Asia. Recently, knowlesi malaria has become the predominant malaria affecting humans in Malaysian Borneo, being responsible for approximately 70% of reported cases. Largely as a result of anthropogenic land use changes in Borneo, vectors which transmit the parasite, along with macaque hosts, are both now frequently found in disturbed forest habitats, or at the forest fringes, thus having more frequent contact with humans. Having access to human hosts provides the parasite with the opportunity to further its adaption to the human immune system. The ecological drivers of the transmission and spread of P. knowlesi are operating over many different spatial (and, therefore, temporal) scales, from the molecular to the continental. Strategies to prevent and manage zoonoses, such as P. knowlesi malaria require interdisciplinary research exploring the impact of land use change and biodiversity loss on the evolving relationship between parasite, reservoir hosts, vectors, and humans over multiple spatial scales. |
Databáze: | OpenAIRE |
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