Effect of Radiotherapy After Breast-Conserving Surgery Depending on the Presence of Tumor-Infiltrating Lymphocytes: A Long-Term Follow-Up of the SweBCG91RT Randomized Trial
Autor: | Per-Uno Malmström, Mårten Fernö, Erik Holmberg, Dan Lundstedt, Anikó Kovács, Martin Sjöström, Linda Werner Hartman, Axel Stenmark Tullberg, Per Karlsson, Elisabeth Werner Rönnerman |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Long term follow up medicine.medical_treatment Breast Neoplasms Triple Negative Breast Neoplasms Mastectomy Segmental law.invention Placebos 03 medical and health sciences 0302 clinical medicine Lymphocytes Tumor-Infiltrating Randomized controlled trial law Internal medicine medicine Breast-conserving surgery Humans Stromal tumor Randomized Controlled Trials as Topic business.industry Tumor-infiltrating lymphocytes Middle Aged Radiation therapy 030104 developmental biology 030220 oncology & carcinogenesis Female Radiotherapy Adjuvant business Adjuvant Mastectomy Follow-Up Studies |
Zdroj: | Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 37(14) |
ISSN: | 1527-7755 |
Popis: | PURPOSE The effects of radiotherapy (RT) on the basis of the presence of stromal tumor infiltrating lymphocytes (TILs) have not been studied. The purpose of this study was to analyze the association of TILs with the effect of postoperative RT on ipsilateral breast tumor recurrence (IBTR) in a large randomized trial. METHODS In the SweBCT91RT (Swedish Breast Cancer Group 91 Radiotherapy) trial, 1,178 patients with breast cancer stage I and II were randomly assigned to breast-conserving surgery plus postoperative RT or breast-conserving surgery only and followed for a median of 15.2 years. Tumor blocks were retrieved from 1,003 patients. Stromal TILs were assessed on whole-section hematoxylin-eosin–stained slides using a dichotomized cutoff of 10%. Subtypes were scored using immunohistochemistry on tissue microarray. In total, 936 patients were evaluated. RESULTS Altogether, 670 (71%) of patients had TILs less than 10%. In a multivariable regression analysis with IBTR as dependent variable and RT, TILs, subtype, age, and grade as independent variables, RT (hazard ratio [HR], 0.42; 95% CI, 0.29 to 0.61; P < .001), high TILs (HR, 0.61; 95% CI, 0.39 to 0.96, P = .033) grade (3 v 1; HR, 2.17; 95% CI, 1.08 to 4.34; P = .029), and age (≥ 50 v < 50 years; HR, 0.55; 95% CI, 0.38 to 0.80; P = .002) were predictive of IBTR. RT was significantly beneficial in the low TILs group (HR, 0.37; 95% CI, 0.24 to 0.58; P < .001) but not in the high TILs group (HR, 0.58; 95% CI, 0.28 to 1.19; P = .138). The test for interaction between RT and TILs was not statistically significant ( P = .317). CONCLUSION This study shows that high values of TILs in the primary tumor independently seem to reduce the risk for an IBTR. Our findings further suggest that patients with breast cancer with low TILs may derive a larger benefit from RT regarding the risk of IBTR. |
Databáze: | OpenAIRE |
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