Comparison of myocardial infarct size assessed with contrast-enhanced magnetic resonance imaging and left ventricular function and volumes to predict mortality in patients with healed myocardial infarction
| Autor: | Theodorus A.M. Kaandorp, Sebastian Kelle, Ernst E. van der Wall, Albert de Roos, Stijntje D. Roes, Hildo J. Lamb, Eckart Fleck, Eike Nagel, Thomas Kokocinski, Jeroen J. Bax, Eric Boersma, Don Poldermans |
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| Přispěvatelé: | Cardiology |
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Myocardial Infarction Ventricular Function Left Coronary artery disease Interquartile range Internal medicine medicine Humans cardiovascular diseases Myocardial infarction Prospective Studies Aged Proportional Hazards Models Ejection fraction medicine.diagnostic_test business.industry Proportional hazards model Hazard ratio Magnetic resonance imaging Stroke Volume Middle Aged medicine.disease Image Enhancement Magnetic Resonance Imaging Survival Analysis Confidence interval cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine business Nuclear medicine Follow-Up Studies |
| Zdroj: | American Journal of Cardiology, 100(6), 930-936. Elsevier Inc. |
| ISSN: | 1879-1913 0002-9149 |
| Popis: | Currently, left ventricular (LV) ejection fraction (EF) and/or LV volumes are the established predictors of mortality in patients with coronary artery disease (CAD) and severe LV dysfunction. With contrast-enhanced magnetic resonance imaging (MRI), precise delineation of infarct size is now possible. The relative merits of LVEF/LV volumes and infarct size to predict long-term outcome are unknown. The purpose of this study was to determine the predictive value of infarct size assessed with contrast-enhanced MRI relative to LVEF and LV volumes for long-term survival in patients with healed myocardial infarction. Cine MRI and contrast-enhanced MRI were performed in 231 patients with healed myocardial infarction. LVEF and LV volumes were measured and infarct size was derived from contrast-enhanced MRI. Nineteen patients (8.2%) died during a median follow-up of 1.7 years (interquartile range 1.1 to 2.9). Cox proportional hazards analysis revealed that infarct size defined as spatial extent (hazard ratio [HR] 1.3, 95% confidence interval [CI] 1.1 to 1.6, chi-square 6.7, p = 0.010), transmurality (HR 1.5, 95% CI 1.1 to 1.9, chi-square 8.9, p = 0.003), or total scar score (HR 6.2, 95% CI 1.7 to 23, chi-square 7.4, p = 0.006) were stronger predictors of all-cause mortality than LVEF and LV volumes. In conclusion, infarct size on contrast-enhanced MRI may be superior to LVEF and LV volumes for predicting long-term mortality in patients with healed myocardial infarction. |
| Databáze: | OpenAIRE |
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