Obesity and impairment of pancreatic β-cell function in early adulthood, independent of obesity age of onset: The Santiago Longitudinal Study
| Autor: | Gladys Barrera, Raquel Burrows, Daniel Bunout, Sheila Gahagan, Elissa Kim, Paulina Correa-Burrows, Estela Blanco, José Rogan |
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| Rok vydání: | 2020 |
| Předmět: |
Longitudinal study
Pediatrics medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism 030204 cardiovascular system & hematology 03 medical and health sciences Young Adult 0302 clinical medicine Endocrinology Insulin resistance Diabetes mellitus Insulin-Secreting Cells Internal Medicine medicine Humans Longitudinal Studies Obesity Age of Onset Chile Preadolescence Adiponectin business.industry nutritional and metabolic diseases medicine.disease Cohort Age of onset business |
| Zdroj: | Diabetes/metabolism research and reviewsREFERENCES. 37(2) |
| ISSN: | 1520-7560 |
| Popis: | Aim We investigated the relation of time of onset and length of obesity with biomarkers of β-cell function in early adulthood in an infancy cohort. Material and methods In 1039 23-year-olds, body-mass index (BMI) was measured at multiple time-points from enrollment. BMI trajectories were interpolated with cubic polynomials. Fasting glucose, insulin and adiponectin were measured at 23 years. Homeostatic model assessment-insulin resistance (HOMA-IR), HOMA-S, HOMA-β, HOMA-adiponectin (AD) and disposition index (DI) were estimated. IR and non-alcoholic fatty liver (NAFL) were diagnosed. According to the BMI trajectory, five groups were defined: participants who were never obese (NOB); participants with obesity starting in adolescence and remained obese into adulthood (recent-onset obesity, ROB); participants who were obese in early childhood but transitioned to non-obesity as preadolescents (former obesity, FOB); participants who were obese in early childhood and remained obese into adulthood (persistent obesity, POB); participants with obesity starting in preadolescence and transitioned to non-obesity as adolescents (transient obesity; TOB). Results Obesity was present in 47% of participants during at least one time-point. ROBs and POBs had higher insulin, HOMA-IR and HOMA-β, lower HOMA-S and DI, and higher prevalence of IR and NAFL at 23 years than NOBs, TOBs and FOBs. No differences were found in the β-cell functionality of NOBs, TOBs and FOBs. Conclusions Persistent and recent obesity are both related to IR, NAFL and a decline of β-cell function in emerging adulthood. Defeating obesity in childhood or adolescence allows reaching emerging adulthood with β-cell functioning similar to that of subjects who were NOB. |
| Databáze: | OpenAIRE |
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