Structure-activity relationships of some arylglycine analogues and catechol isosteres of BRL 36650, a 6.ALPHA.-formamido penicillin

Autor:	David T. Davies, Desmond John Best, Andrew V. Stachulski, George Burton, Terence C. Smale, Robert Southgate, John S. Elder, Sarah J. Knott, Michael J. Basker
Rok vydání:	1990
Předmět:	Pharmacology Catechol Bacteria Molecular Structure Stereochemistry organic chemicals Alpha (ethology) Penicillins Penicillin Structure-Activity Relationship chemistry.chemical_compound chemistry Drug Discovery medicine bacteria Derivative (chemistry) medicine.drug
Zdroj:	The Journal of Antibiotics. 43:574-577
ISSN:	1881-1469 0021-8820
Popis:	The catecholic acylureido derivative BRL 36650 was the most potent, especially against Pseudomonas aeruginosa strains. We now report on analogues of 1 which either retain a catechol or dihydroxyphenyl unit or contain various catechol isosteres.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59cae026828d392eab8d9dd5bf9193fc https://doi.org/10.7164/antibiotics.43.574 Zobrazit plný text záznamu