MUC1 marks collecting tubules, renal vesicles, comma- and S-shaped bodies in human developing kidney
| Autor: | Gavino Faa, Nicoletta Iacovidou, Annalisa Locci, Daniela Fanni, Clara Gerosa, P Van Eyken, Vassilios Fanos, Guido Monga, Sonia Nemolato, S Mellou |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty Histology Mesenchyme comma and S-shaped bodies Biophysics MUC1 nephrogenesis Biology Kidney digestive system Fetal Kidney 03 medical and health sciences 0302 clinical medicine fetal kdney medicine Humans Kidney Tubules Collecting skin and connective tissue diseases neoplasms renal vesicles 030304 developmental biology 0303 health sciences Original Paper Mesenchymal stem cell Mucin-1 Gene Expression Regulation Developmental Cell Biology Embryonic stem cell Immunohistochemistry biological factors digestive system diseases collecting tubules medicine.anatomical_structure 030220 oncology & carcinogenesis Ureteric bud |
| Zdroj: | European Journal of Histochemistry : EJH |
| ISSN: | 2038-8306 1121-760X |
| Popis: | MUC1 is a transmembrane glycoprotein, apically expressed in most epithelial cells, used in the differential diagnosis of carcinomas and for discrimination of tumors of non-epithelial origin showing epithelioid features. Little attention has been paid so far though, on its possible significance in embryonic tissues. A preliminary study from our group revealed MUC1 expression in the cap mesenchymal cells during human nephrogenesis, suggesting a role for MUC1 in the process of mesenchymal-to-epithelial transition. This study aimed at investigating the expression pattern of MUC1 in various developing structures of human fetal kidney. Expression of MUC1 was examined in kidneys of 5 human fetuses. MUC1 immunoreactivity was detected in ureteric bud tips, in collecting tubules, in cap mesenchymal cells undergoing the initial phases of mesenchymal-to-epithelial transition, in renal vesicles, comma-bodies, and S-shaped bodies. Our previous preliminary report suggested a role for MUC1 in the initial phases of the process of mesenchymal-to-epithelial transition. The present data suggest that MUC1 expression characterizes multiple structures during human nephrogenesis, from the ureteric bud, to the initial phases of mesenchymal-to-epithelial transition and that MUC1 should be added to the genes activated during the process of mesenchymal-to-epithelial transition in the cap mesenchyme of human kidney. |
| Databáze: | OpenAIRE |
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