Effects of in utero and postnatal sodium saccharin exposure on the nutritional status of the young rat. II. Dose response and reversibility
| Autor: | Samuel M. Cohen, R. Shapiro, B. J. Mattson, P. L. Kraft, J. M. Parr, Emily M. Garland |
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| Rok vydání: | 1991 |
| Předmět: |
Vitamin
Male medicine.medical_specialty medicine.medical_treatment Weanling Nutritional Status Toxicology chemistry.chemical_compound Folic Acid Saccharin Pregnancy Internal medicine medicine Animals Vitamin E Vitamin A Triglyceride Dose-Response Relationship Drug business.industry Body Weight Rats Inbred Strains General Medicine Rats Endocrinology chemistry Blood chemistry Liver Urinary Bladder Neoplasms In utero Prenatal Exposure Delayed Effects Toxicity Female business Food Science |
| Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 29(10) |
| ISSN: | 0278-6915 |
| Popis: | A previous study in our laboratory demonstrated that 30-day-old Sprague-Dawley rats exposed to 7.5% sodium saccharin (NaS) since conception differ from untreated rats in several physiological parameters. In the present study, to determine the dose response of the changes associated with NaS treatment, animals were evaluated at 30 days post-birth, after treatment with dietary levels of 0, 1, 3 or 7.5% NaS since conception. Most physiological consequences of NaS treatment in the weanling rat, including anaemia and reductions in serum folate and vitamin A concentrations, were dose dependent. Serum vitamin E, cholesterol and triglyceride concentrations were decreased at the two lower doses of NaS but were significantly increased with 7.5% NaS. The no-effect level (NOEL) was similar for physiological effects and for bladder tumour production in two-generation studies (1% NaS in the diet). The reversibility of the effects of 7.5% NaS was examined in 90-day-old rats. The increases in lipids and vitamin E were reversible. Although values for haematological parameters and serum vitamin A remained significantly reduced at 90 days, changes were less severe than at 30 days. Histological examinations revealed that the effects of 7.5% dietary NaS on the bladder were negligible, indicating that the physiological changes observed in the young rat are probably not directly related to the production of bladder tumours. |
| Databáze: | OpenAIRE |
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