Chicken embryo model for type III group B beta-hemolytic streptococcal septicemia
| Autor: | Lawrence C. Vogel, J Tieffenberg, Roberto R. Kretschmer, S P Gotoff, D. Padnos |
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| Rok vydání: | 1978 |
| Předmět: |
animal structures
Immunology Virulence Heterologous Chick Embryo Biology Hemolysis Microbiology Group B Streptococcus agalactiae Immunity Sepsis Streptococcal Infections Homologous chromosome Animals Antiserum Inoculation Embryo Virology Disease Models Animal Infectious Diseases embryonic structures Parasitology Immunity Maternally-Acquired Research Article |
| Zdroj: | Infection and Immunity. 19:481-485 |
| ISSN: | 1098-5522 0019-9567 |
| Popis: | A lethal septicemia was induced in 11- and 12-day-old chicken embryos with intravenous inoculation of relatively small numbers of a clinical isolate (GBBHS-III-Bell) or a reference strain (GBBHS-III-D136-C) of group B beta-hemolytic streptococci (GBBHS). GBBHS-III-Bell was more virulent than GBBHS-III-D136-C, and 11-day-old chicken embryos were more susceptible than 12-day-old chicken embryos. Type-specific rabbit antisera protected the embryos from bacterial challenge, and this protective effect was absorbed with homologous but not heterologous GBBHS strains. A heterologous antiserum and normal rabbit sera provided some protection, which could be absorbed with either homologous or heterologous GBBHS strains. The chicken embryo is a suitable animal model for the study of infection and immunity with GBBHS type III. |
| Databáze: | OpenAIRE |
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