Early versus late-phase consolidation of opiate reward memories requires distinct molecular and temporal mechanisms in the amygdala-prefrontal cortical pathway
| Autor: | Melanie Bechard, Steven R. Laviolette, Lique M. Coolen, Xavier De Jaeger, Ninglei Sun, Shervin Gholizadeh |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
lcsh:Medicine Neurological Signaling Behavioral Neuroscience 0302 clinical medicine Cognition Learning and Memory Molecular Cell Biology Neurobiology of Disease and Regeneration Signaling in Cellular Processes Prefrontal cortex lcsh:Science 0303 health sciences Multidisciplinary Consolidation (soil) Neurotransmitters Signaling in Selected Disciplines Amygdala Signaling Cascades Analgesics Opioid medicine.anatomical_structure Anesthesia Memory consolidation Opiate Psychology psychological phenomena and processes Research Article Signal Transduction Cognitive Neuroscience Prefrontal Cortex Signaling Pathways 03 medical and health sciences Neuropsychology Memory Ca2+/calmodulin-dependent protein kinase medicine Animals Calcium Signaling Biology 030304 developmental biology Recall Mechanism (biology) lcsh:R Animal Cognition Rats nervous system Calcium Signaling Cascade lcsh:Q Molecular Neuroscience Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | PLoS ONE, Vol 8, Iss 5, p e63612 (2013) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | The consolidation of newly acquired memories involves the temporal transition from a recent, less stable trace to a more permanent consolidated form. Opiates possess potent rewarding effects and produce powerful associative memories. The activation of these memories is associated with opiate abuse relapse phenomena and the persistence of compulsive opiate dependence. However, the neuronal, molecular and temporal mechanisms by which associative opiate reward memories are consolidated are not currently understood. We report that the consolidation of associative opiate reward memories involves a temporal and molecular switch between the basolateral nucleus of the amygdala (BLA) (early consolidation phase) to the medial prefrontal cortex (mPFC) (late consolidation phase). We demonstrate at the molecular, behavioral and neuronal levels that the consolidation of a recently acquired opiate reward memory involves an extracellular signal-related kinase (ERK)-dependent phosphorylation process within the BLA. In contrast, later-stage consolidation of a newly acquired memory is dependent upon a calcium-calmodulin-dependent (CaMKII), ERK-independent, mechanism in the mPFC, over a 12 hr temporal gradient. In addition, using in vivo multi-unit neuronal recordings in the mPFC, we report that protein synthesis within the BLA modulates the consolidation of opiate-reward memory in neuronal mPFC sub-populations, via the same temporal dynamic. |
| Databáze: | OpenAIRE |
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