Hypnotic effect of tryptophan analog in rats
| Autor: | Hans G. Schlossberger, Walter J. Wojcik, Miodrag Radulovacki, Casimir Fornal |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
medicine.medical_specialty Serotonin medicine.drug_class Metabolite Clinical Biochemistry Hippocampus Toxicology Biochemistry Hypnotic Behavioral Neuroscience chemistry.chemical_compound Catecholamines Dopamine Internal medicine medicine Animals Hypnotics and Sedatives Biological Psychiatry Tryptophan analog Pharmacology Brain Chemistry Electromyography Homovanillic acid Tryptophan Electroencephalography Hydroxyindoleacetic Acid Cortex (botany) Electrodes Implanted Rats Endocrinology chemistry Sleep medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 11(3) |
| ISSN: | 0091-3057 |
| Popis: | The effects of DL 2-amino-3-(1-naphthyl) propanoic acid, a tryptophan analog, on sleep and brain chemistry were investigated in rats. Similar to previous findings with tryptophan, the tryptophan analog (30 mg/kg, IP) reduced slow-wave sleep (SWS) latency. The reduction in SWS latency occurred at a time when 5-hydroxytryptamine (5-HT) concentration was reduced in the cortex, pons-medulla and striatum-thalamus with no change in the concentration of 5-hydroxyindoleacetic acid, a major metabolite of 5-HT. At the same time, norepinephrine concentration was reduced in the cortex, hippocampus and striatum-thalamus with a marked reduction (40%) in cortical dopamine (DA). The reduction of cortical DA coincided with a 53% decrease in homovanillic acid, a major metabolite of DA. The behavioral effect of tryptophan analog for six hours, as monitored by the EEG, was an increase in SWS by 25 min and a decrease in walking by 29 min. These data suggest that the effects of the tryptophan analog on sleep may be due to the attenuation of the activity of brain catecholamines and imply that tryptophan may as well produce its hypnotic effect via a similar mechanism. |
| Databáze: | OpenAIRE |
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