The role of the liver in the uptake of plasma and chyle triglycerides in the rat
| Autor: | Michael C. Schotz, Thomas Olivecrona, Bo Arnesjö |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
medicine.medical_specialty
Chyle Glyceride Lipoproteins Biophysics Phospholipid Palmitic Acids Tritium Biochemistry Glycerides Palmitic acid chemistry.chemical_compound Hydrolysis Endocrinology Internal medicine medicine Dietary Carbohydrates Animals Phospholipids Triglycerides Carbon Isotopes Triglyceride Chemistry Fatty Acids Rats Liver Injections Intravenous Chylomicron Lipoprotein |
| Zdroj: | Biochimica et biophysica acta. 125(3) |
| ISSN: | 0006-3002 |
| Popis: | 1. 1. Recently it has been proposed that chylomicron triglyceride cannot be metabolized directly by the liver. In order to test this proposal, two experiments were performed. Chyle and serum lipoproteins, respectively, labeled with [3H]palmitic acid in the glyceride moieties, were injected into unanesthetized fasted and carbohydraterefed rats. It was assumed that liver phospholipids would be mainly labeled only through the incorporation of fatty acids liberated upon hydrolysis of the labeled chyle or serum lipoprotein glyceride. The liver phospholipid radioactivity thus gave a measure of the incorporation of liberated fatty acids into the liver lipid esters. This was compared with the calculated flux of label through the plasma free fatty acid pool into the liver. It was found that this flux was insufficient to explain the entire incorporation of label into the liver lipid esters except perhaps in the fasted group of rats injected with chyle. This indicates that some of the chyle or serum lipo-protein triglyceride was hydrolyzed in the liver. 2. 2. Labeled serum lipoprotein triglyceride initially disappeared from the circulation faster than labeled chyle triglyceride. With the serum lipoprotein triglyceride, but not with the chyle triglyceride the initial rate of disappearance was more rapid in fasted than in carbohydrate-refed rats. 3. 3. No major differences were found between anesthetized and unanesthetized rats with regard to rate of removal of chyle label or uptake of this labeled material by the liver. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|