Stimulation of central 5-HT1D receptors causes hypothermia in the guinea-pig
| Autor: | M. Skingle, Guy A. Higgins, W. Feniuk |
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| Rok vydání: | 1994 |
| Předmět: |
Agonist
Spiperone Metergoline medicine.medical_specialty medicine.drug_class Ritanserin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Pharmacology (medical) Receptor 5-HT receptor Pharmacology business.industry Hypothermia Receptor antagonist 030227 psychiatry Psychiatry and Mental health Endocrinology chemistry medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Psychopharmacology. 8:14-21 |
| ISSN: | 1461-7285 0269-8811 |
| DOI: | 10.1177/026988119400800103 |
| Popis: | The 5-HT1 receptor agonist GR46611 (3-30 mg/kg s.c.) caused a dose-related decrease in rectal temperature in the adult guinea-pig. A lower dose (20 μg) administered directly into the lateral cerebral ventricle also caused a hypothermic response, suggesting that this effect is centrally mediated. GR46611-induced (10 mg/kg s.c.) hypothermia was not attenuated by WAY100135 (3-10 mg/kg s.c.), ritanserin (0.3-1 mg/kg s.c.), spiperone (0.1-0.3 mg/kg s.c.) and ondansetron (0.1-1 mg/kg s.c.), suggesting that 5-HT1A, 5-HT2A, 5-HT 2C and 5-HT3 receptors are unlikely to be involved in this response. In contrast, the poorly selective 5-HT receptor antagonist, metergoline (1-10 mg/kg s.c.), and the potent 5-HT1D receptor antagonist, GR127935 (0.1-1 mg/kg p.o.), antagonized the effects of GR46611. The present data suggest that antagonism of GR46611-induced hypothermia may be useful for assessing the potency and duration of action of centrally-acting 5-HT 1D receptor antagonists in the guinea-pig. |
| Databáze: | OpenAIRE |
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