Prior beta blockers use is independently associated with increased inpatient mortality in patients presenting with acute myocardial infarction
| Autor: | Suzhen Chen, Xiang Zhu, Junhong Gui, Khalid Abusaada, Yan Zhou |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty medicine.drug_class medicine.medical_treatment Adrenergic beta-Antagonists Myocardial Infarction 030204 cardiovascular system & hematology Cohort Studies Coronary artery disease 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Hospital Mortality Registries 030212 general & internal medicine Myocardial infarction Beta blocker Aged Retrospective Studies business.industry Incidence (epidemiology) Percutaneous coronary intervention Retrospective cohort study Odds ratio Middle Aged medicine.disease Hospitalization Heart failure Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | International Journal of Cardiology. 243:81-85 |
| ISSN: | 0167-5273 |
| Popis: | Beta blockers (BBs) are recommended for patients presenting with acute myocardial infarction. However, the effects of prior BBs use on inpatient mortality in patients presenting with acute myocardial infarction (AMI) are unknown.This was a retrospective cohort study of patients presenting with AMI in Florida Hospital Orlando from January 1, 2013 to December 31, 2014. Data were collected prospectively, as part of the Acute Coronary Treatment and Intervention Outcomes Network (ACTION) Registry.1128 patients were included in the analysis, with 354 (31.4%) patients on home BBs and 774 (68.6%) not on home BBs on presentation. Patients in prior BBs group were older, had higher incidence of multiple comorbidities, and were more likely to take cardiovascular medications. During hospitalization, Patients in prior BBs group were more likely to develop decompensated heart failure (9.9% vs. 3.6%, P0.001), less likely to have STEMI (33.9% vs. 54.4%, P0.001), and subsequently less PCI (73.2% vs. 81.3%, P=0.002), but higher inpatient mortality (8.8% vs. 4.8%, P=0.009). In multivariable logistic regression analysis, prior BBs use was independently associated with increased inpatient mortality (adjusted OR 3.15, 95% CI 1.44-6.87, P=0.004), as well as in GRACE model (adjusted ratio=1.83, 95% CI 1.01-3.34, P0.047). However, prior BBs use did not contribute significantly to predict inpatient mortality on the basis of GRACE model in terms of discrimination and calibration.Prior BBs use was independently associated with increased inpatient mortality, and should be considered a high risk marker for patients presenting with acute myocardial infarction. |
| Databáze: | OpenAIRE |
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