Lack of specific association between panicogenic properties of caffeine and HPA-axis activation. A placebo-controlled study of caffeine challenge in patients with panic disorder
| Autor: | Manolis Markianos, Panagiotis Oulis, Vasilios G. Masdrakis |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Hypothalamo-Hypophyseal System endocrine system medicine.medical_specialty Hydrocortisone Pituitary-Adrenal System Adrenocorticotropic hormone Placebo chemistry.chemical_compound Dehydroepiandrosterone sulfate Adrenocorticotropic Hormone Double-Blind Method Caffeine Internal medicine medicine Humans Biological Psychiatry Cross-Over Studies Dehydroepiandrosterone Sulfate Panic disorder Panic Middle Aged medicine.disease Psychiatry and Mental health medicine.anatomical_structure Endocrinology chemistry Panic Disorder Female medicine.symptom Arousal Psychology hormones hormone substitutes and hormone antagonists Hypothalamic–pituitary–adrenal axis medicine.drug |
| Zdroj: | Psychiatry Research. 229:75-81 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/j.psychres.2015.07.069 |
| Popis: | A subgroup of patients with Panic Disorder (PD) exhibits increased sensitivity to caffeine administration. However, the association between caffeine-induced panic attacks and post-caffeine hypothalamic-pituitary-adrenal (HPA)-axis activation in PD patients remains unclear. In a randomized, double-blind, cross-over experiment, 19 PD patients underwent a 400-mg caffeine-challenge and a placebo-challenge, both administered in the form of instant coffee. Plasma levels of adrenocorticotropic hormone (ACTH), cortisol and dehydroepiandrosterone sulfate (DHEAS) were assessed at both baseline and post-challenge. No patient panicked after placebo-challenge, while nine patients (47.3%) panicked after caffeine-challenge. Placebo administration did not result in any significant change in hormones' plasma levels. Overall, sample's patients demonstrated significant increases in ACTH, cortisol, and DHEAS plasma levels after caffeine administration. However, post-caffeine panickers and non-panickers did not differ with respect to the magnitude of the increases. Our results indicate that in PD patients, caffeine-induced panic attacks are not specifically associated with HPA-axis activation, as this is reflected in post-caffeine increases in ACTH, cortisol and DHEAS plasma levels, suggesting that caffeine-induced panic attacks in PD patients are not specifically mediated by the biological processes underlying fear or stress. More generally, our results add to the evidence that HPA-axis activation is not a specific characteristic of panic. |
| Databáze: | OpenAIRE |
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