Pulse cyclophosphamide therapy in Wegener's granulomatosis: a pilot study
| Autor: | Alexandros A. Drosos, Kostas C. Siamopoulos, Haralampos M. Moutsopoulos, Anna Goussia, L. I. Sakkas |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Systemic disease medicine.medical_specialty Cyclophosphamide Exacerbation Adolescent medicine.medical_treatment Administration Oral Pilot Projects Drug Administration Schedule Oral administration Internal Medicine medicine Humans Infusions Intravenous Aged Wegener s Chemotherapy business.industry Granulomatosis with Polyangiitis Pulse cyclophosphamide Middle Aged medicine.disease Surgery Regimen Treatment Outcome business medicine.drug |
| Zdroj: | Journal of internal medicine. 232(3) |
| ISSN: | 0954-6820 |
| Popis: | Five patients with Wegener's granulomatosis (WG) have been treated with 6- to 8-monthly pulses of intravenous cyclophosphamide (CP) and glucocorticoids in an open pilot study. One patient achieved complete remission sustained during 30 months of follow-up; one patient had features of active disease after 28 months of remission; two patients after an initial remission had an exacerbation of the disease and received continuous oral administration of CP, and one patient required continuous oral CP to control the symptoms. These results suggest that this regimen may not achieve a high degree of sustained remission in patients with WG. |
| Databáze: | OpenAIRE |
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