Biological fate of low-calorie sweeteners
| Autor: | Andrew G. Renwick, Bernadene A. Magnuson, Michael C. Carakostas, Sylvia P. Poulos, Nadia H. Moore |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Sucralose Sucrose Acesulfame potassium Thiazines Medicine (miscellaneous) 030209 endocrinology & metabolism Health benefits 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Saccharin Glucosides Diabetes Mellitus Animals Humans Aspartame Gut microflora 030109 nutrition & dietetics Nutrition and Dietetics business.industry Microbiota Low calorie Legislation Drug Biotechnology chemistry Sweetening Agents business Diterpenes Kaurane Energy Intake Steviol glycoside |
| Zdroj: | Nutrition reviews. 74(11) |
| ISSN: | 1753-4887 |
| Popis: | With continued efforts to find solutions to rising rates of obesity and diabetes, there is increased interest in the potential health benefits of the use of low- and no-calorie sweeteners (LNCSs). Concerns about safety often deter the use of LNCSs as a tool in helping control caloric intake, even though the safety of LNCS use has been affirmed by regulatory agencies worldwide. In many cases, an understanding of the biological fate of the different LNSCs can help health professionals to address safety concerns. The objectives of this review are to compare the similarities and differences in the chemistry, regulatory status, and biological fate (including absorption, distribution, metabolism, and excretion) of the commonly used LNCSs: acesulfame potassium, aspartame, saccharin, stevia leaf extract (steviol glycoside), and sucralose. Understanding the biological fate of the different LNCSs is helpful in evaluating whether reports of biological effects in animal studies or in humans are indicative of possible safety concerns. Illustrations of the usefulness of this information to address questions about LNCSs include discussion of systemic exposure to LNCSs, the use of sweetener combinations, and the potential for effects of LNCSs on the gut microflora. |
| Databáze: | OpenAIRE |
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