Mechanical Flexibility of DNA: A Quintessential Tool for DNA Nanotechnology
| Autor: | Runjhun Saran, Yong Wang, Isaac T. S. Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Nanotechnology 02 engineering and technology Review DNA nanostructures Molecular Dynamics Simulation lcsh:Chemical technology biosensor Biochemistry Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound Rigidity (electromagnetism) DNA stiffness DNA nanotechnology DNA origami lcsh:TP1-1185 Electrical and Electronic Engineering Instrumentation 030304 developmental biology chemistry.chemical_classification Flexibility (engineering) 0303 health sciences DNA bending Biomolecule Flexural rigidity DNA 021001 nanoscience & nanotechnology Atomic and Molecular Physics and Optics Nanostructures Applications of nanotechnology chemistry Nucleic Acid Conformation 0210 nano-technology |
| Zdroj: | Sensors (Basel, Switzerland) Sensors, Vol 20, Iss 7019, p 7019 (2020) |
| DOI: | 10.14288/1.0395476 |
| Popis: | The mechanical properties of DNA have enabled it to be a structural and sensory element in many nanotechnology applications. While specific base-pairing interactions and secondary structure formation have been the most widely utilized mechanism in designing DNA nanodevices and biosensors, the intrinsic mechanical rigidity and flexibility are often overlooked. In this article, we will discuss the biochemical and biophysical origin of double-stranded DNA rigidity and how environmental and intrinsic factors such as salt, temperature, sequence, and small molecules influence it. We will then take a critical look at three areas of applications of DNA bending rigidity. First, we will discuss how DNA’s bending rigidity has been utilized to create molecular springs that regulate the activities of biomolecules and cellular processes. Second, we will discuss how the nanomechanical response induced by DNA rigidity has been used to create conformational changes as sensors for molecular force, pH, metal ions, small molecules, and protein interactions. Lastly, we will discuss how DNA’s rigidity enabled its application in creating DNA-based nanostructures from DNA origami to nanomachines. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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