Homocysteine might increase the risk of recurrence in patients presenting with primary cerebral infarction
| Autor: | Jianati Anniwaer, Ke-Dong Xue, Meng-Zhuang Liu, Aersilan Xiamixiding, Abuduzhayier Maimaiti |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male congenital hereditary and neonatal diseases and abnormalities Hyperhomocysteinemia medicine.medical_specialty Homocysteine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Recurrence Risk Factors Internal medicine medicine Humans In patient cardiovascular diseases Prospective Studies Risk factor Aged Cerebral infarction business.industry General Neuroscience nutritional and metabolic diseases General Medicine Cerebral Infarction Middle Aged medicine.disease 030104 developmental biology chemistry cardiovascular system Cardiology Female business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | The International journal of neuroscience. 129(7) |
| ISSN: | 1563-5279 |
| Popis: | Although hyperhomocysteinemia (Hhcy) is a risk factor for cerebral infarction, its effect on recurrent cerebral infarction is less-defined. We aimed to investigate the association of Hhcy and increased risk of recurrent cerebral infarct.From 2011 to 2013, we recruited 231 primary cerebral infarct patients that were divided to a Hhcy group (n = 105) and a control group (n = 126) according to plasma homocysteinemia (Hcy) levels exceeding 15 μmol/L. In this prospective study, risk factors such as gender, age, blood lipid and glucose levels, history of diabetes, high blood pressure, smoking habits and plasma Hhcy levels were determined. A three-year follow-up compared differences in cerebral infarction recurrence rates. Statistical analyses identified whether plasma Hhcy levels were an independent risk factor for recurrent cerebral infarction.Triglyceride and low-density lipoprotein (LDL) levels in the Hhcy group were significantly higher than controls, and cerebral infarct recurrence rates in the Hhcy group exceeded control subject rates through the three-year follow-up (p = .021, p = .036 and p = .025). Cox proportional hazards modeling showed that elevated Hhcy levels (hazard ratio [HR] = 3.062, p .001), increased age (HR = 1.069, p .01), circulating triglyceride levels (HR = 1.686, p = .048), and relative National Institutes of Health Stroke (NIHSS) score (HR = 1.068, p = .016) were risk factors for recurrent cerebral infarction.Level of Hhcy was a risk factor for recurrent cerebral infarction. Further, particular demographic and clinical outcomes including age, relative NIHSS scores, and circulating triglyceride levels were markedly associated with the occurrence of cerebral infarction. |
| Databáze: | OpenAIRE |
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