Comparative study of chronic kidney disease in dogs and cats: Induction of myofibroblasts
| Autor: | Yasuyuki Endo, Makoto Fujiki, Sawane Mitani, Akira Yabuki, Kazuhiro Misumi, Noriaki Miyoshi, Osamu Yamato |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pathology
medicine.medical_specialty CATS General Veterinary biology Glomerulosclerosis Vimentin macromolecular substances Glomerular Hypertrophy Cat Diseases Kidney medicine.disease Interstitial cell Dogs Glomerulonephritis Fibrosis Creatinine Cats biology.protein medicine Animals Kidney Failure Chronic Dog Diseases Myofibroblast Kidney disease |
| Zdroj: | Research in Veterinary Science. 88:294-299 |
| ISSN: | 0034-5288 |
| DOI: | 10.1016/j.rvsc.2009.09.003 |
| Popis: | We investigated the kidneys of dogs and cats to clarify whether renal myofibroblasts induction is associated with the severity of chronic kidney disease (CKD). Immunohistochemical expression of myofibroblast markers, alpha-smooth muscle actin (SMA) and vimentin, were evaluated quantitatively. The degrees of glomerulosclerosis, glomerular hypertrophy, interstitial cell infiltration, and interstitial fibrosis were also evaluated quantitatively. The plasma creatinine (pCre) concentrations correlated with glomerulosclerosis, cell infiltration, and fibrosis in dogs, and only with fibrosis in cats. The alpha-SMA expression correlated with pCre, glomerulosclerosis, cell infiltration, and fibrosis in dogs, and with pCre and fibrosis in cats. Tubular vimentin expression correlated with fibrosis in cats, but not in dogs. Interstitial vimentin expression correlated with pCre, glomerulosclerosis, cell infiltration, and fibrosis in dogs, but only with pCre in cats. In conclusion, it was suggested that the severity of CKD in dogs and cats was mediated by different pathways associated with myofibroblasts expression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect