Genomic resources for a unique, low-virulence Babesia taxon from China
| Autor: | Youquan Li, Anson V. Koehler, Neil D. Young, Zhijie Liu, Tao Wang, Guiquan Guan, Robin B. Gasser, Jianxun Luo, Hong Yin, Pasi K. Korhonen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty China Babesia Cattle Diseases Sheep Diseases Virulence Polymerase Chain Reaction Synteny Genome lcsh:Infectious and parasitic diseases 03 medical and health sciences Babesia sp. Xinjiang Variant erythrocyte surface antigens (VESAs) Babesiosis Molecular genetics medicine Animals lcsh:RC109-216 Phylogeny 2. Zero hunger Genetics Sheep 030102 biochemistry & molecular biology biology Research Molecular Sequence Annotation Babesia bovis Sequence Analysis DNA DNA Protozoan biology.organism_classification medicine.disease 030104 developmental biology Infectious Diseases Parasitology Immunology Cattle Genome Protozoan |
| Zdroj: | Parasites & Vectors, Vol 9, Iss 1, Pp 1-8 (2016) Parasites & Vectors |
| ISSN: | 1756-3305 |
| DOI: | 10.1186/s13071-016-1846-1 |
| Popis: | Background Babesiosis is a socioeconomically important tick-borne disease of animals (including humans) caused by haemoprotozoan parasites. The severity of babesiosis relates to host and parasite factors, particularly virulence/pathogenicity. Although Babesia bovis is a particularly pathogenic species of cattle, there are species of Babesia of ruminants that have limited pathogenicity. For instance, the operational taxonomic unit Babesia sp. Xinjiang (abbreviated here as Bx) of sheep from China is substantially less virulent/pathogenic than B. bovis is in cattle. Although the reason for this distinctiveness is presently unknown, it is possible that Bx has a reduced ability to adhere to cells or evade/suppress immune responses, which might relate to particular proteins, such as the variant erythrocyte surface antigens (VESAs). Results We sequenced and annotated the 8.4 Mb nuclear draft genome of Bx and compared it with those of B. bovis and B. bigemina by synteny analysis; we also investigated the genetic relationship of Bx with selected Babesia species and related apicomplexans for which genomic datasets are available, and explored the VESA complement in Bx. Conclusions The availability of the Bx genome now provides unique opportunities to elucidate aspects of the molecular biology, biochemistry and physiology of Bx, and to explore the reason(s) for its limited virulence and/or apparent ability to evade immune attack by the host animal. Moreover, the present genomic resource and an in vitro culture system for Bx raises the prospect of establishing a functional genomic platform to explore essential genes as new intervention targets against babesiosis. Electronic supplementary material The online version of this article (doi:10.1186/s13071-016-1846-1) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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