Modifying the Temporal Profile of the High-Potency Sweetener Neotame
| Autor: | D. E. Walters, Nitin Desai, Bishay Ie, Indra Prakash |
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| Rok vydání: | 2000 |
| Předmět: |
Models
Molecular Taste Molecular model Stereochemistry Molecular Conformation Dipeptides General Chemistry Serine chemistry.chemical_compound Drug Stability chemistry Cinnamates Sweetening Agents Neotame Tyrosine Potency Molecule General Agricultural and Biological Sciences Monte Carlo Method Conformational isomerism |
| Zdroj: | Journal of Agricultural and Food Chemistry. 49:786-789 |
| ISSN: | 1520-5118 0021-8561 |
| Popis: | It is possible, using hydrophobic organic acids (such as cinnamate) or hydroxyamino acids (such as serine and tyrosine), to modify the temporal profile of the high-potency sweetener neotame. On the basis of Monte Carlo simulations, it was concluded that it is unlikely that this effect is due to direct interaction between the neotame molecule and the taste modifier. It is shown, using conformational analysis and molecular modeling, that the taste modifiers can adopt low-energy conformers which mimic the proposed active conformation of neotame, which suggests that the modifiers may compete for binding at the receptor site. |
| Databáze: | OpenAIRE |
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